Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life
Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life
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DOI：
10.1016/j.chom.2015.05.012
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发表时间：
2015-05-13
影响因子：
30.3
通讯作者：
Jun, Wang
中科院分区：
文献类型：
--
作者：
Backhed, Fredrik;Roswall, Josefine;Jun, Wang
肠道微生物群对人类健康至关重要，但其在生命早期的建立尚未进行定量和功能性研究。对来自瑞典婴儿及其母亲的大队列粪便样本进行宏基因组分析，我们描述了生命第一年的肠道微生物组，并评估了分娩和喂养方式对其建立的影响。与阴道分娩的婴儿相比，剖腹产婴儿的肠道微生物群与母亲的相似性明显降低。营养对早期微生物群的组成和功能有重大影响，停止母乳喂养，而不是引入固体食物，是成熟为成人样微生物群所必需的。微生物群组成和生态网络在每个采样阶段都具有独特的特征，与微生物群的功能成熟一致。我们的研究结果建立了一个框架，以了解肠道微生物组和人体在生命早期之间的相互作用。
The gut microbiota is central to human health, but its establishment in early life has not been quantitatively and functionally examined. Applying metagenomic analysis on fecal samples from a large cohort of Swedish infants and their mothers, we characterized the gut microbiome during the first year of life and assessed the impact of mode of delivery and feeding on its establishment. In contrast to vaginally delivered infants, the gut microbiota of infants delivered by C-section showed significantly less resemblance to their mothers. Nutrition had a major impact on early microbiota composition and function, with cessation of breast-feeding, rather than introduction of solid food, being required for maturation into an adult-like microbiota. Microbiota composition and ecological network had distinctive features at each sampled stage, in accordance with functional maturation of the microbiome. Our findings establish a framework for understanding the interplay between the gut microbiome and the human body in early life.