Hepatitis B surface antigen could contribute to the immunopathogenesis of hepatitis B virus infection.
Hepatitis B surface antigen could contribute to the immunopathogenesis of hepatitis B virus infection.
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DOI：
10.1155/2013/935295
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Shimosegawa T
中科院分区：
文献类型：
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作者：
Kondo Y;Ninomiya M;Kakazu E;Kimura O;Shimosegawa T
关于乙型肝炎病毒(乙肝病毒)感染急性期和慢性期表面抗原定量变化的临床意义的各种研究结果已有报道。除了作为乙肝病毒复制活性的生物标志物外，已有研究表明，乙肝表面抗原可能在乙肝持续感染的免疫发病机制中起作用。此外，由于针对乙肝表面抗原的细胞和体液免疫应答可能能够控制乙肝病毒的复制和生命周期，因此，乙肝表面抗原可能成为免疫治疗的一个有吸引力的靶点。然而，一些报道描述了乙肝表面抗原的免疫抑制功能。乙肝表面抗原可能通过直接相互作用抑制单核细胞、树突状细胞、自然杀伤细胞和自然杀伤T细胞。另一方面，细胞毒性T淋巴细胞(CTL)和辅助性T(Th)细胞被高剂量的HBSAg耗尽。在本文中，我们将重点放在乙肝表面抗原的免疫学方面，因为更好地了解乙肝表面抗原与免疫细胞之间的相互作用有助于免疫治疗的发展，以及作为衡量乙肝病毒持续感染状态的生物标志物。
Various findings concerning the clinical significance of quantitative changes in hepatitis B surface antigen (HBsAg) during the acute and chronic phase of hepatitis B virus (HBV) infection have been reported. In addition to being a biomarker of HBV-replication activity, it has been reported that HBsAg could contribute to the immunopathogenesis of HBV persistent infection. Moreover, HBsAg could become an attractive target for immune therapy, since the cellular and humeral immune response against HBsAg might be able to control the HBV replication and life cycle. However, several reports have described the immune suppressive function of HBsAg. HBsAg might suppress monocytes, dendritic cells (DCs), natural killer (NK), and natural killer T (NK-T) cells by direct interaction. On the other hand, cytotoxic T lymphocytes (CTLs) and helper T (Th) cells were exhausted by high amounts of HBsAg. In this paper, we focused on the immunological aspects of HBsAg, since better understanding of the interaction between HBsAg and immune cells could contribute to the development of an immune therapy as well as a biomarker of the state of HBV persistent infection.