Thyroid carcinoma in Hiroshima and Nagasaki. I. Prevalence of thyroid carcinoma at autopsy.
Thyroid carcinoma in Hiroshima and Nagasaki. I. Prevalence of thyroid carcinoma at autopsy.
复制标题
广岛和长崎的甲状腺癌。
DOI：
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发表时间：
1969
期刊：
影响因子：
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通讯作者：
S. Iijima
中科院分区：
文献类型：
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作者：
R. Sampson;C. Key;C. Buncher;S. Iijima
尸检中发现的甲状腺癌在日本的发生率远远高于任何有记录的美国系列。日本国立卫生研究所-原子弹爆炸伤亡委员会在广岛和长崎进行的寿命研究的固定人群样本中，有3,067例连续尸检，发现536例原发性甲状腺癌-97%为隐匿性乳头状癌。妇女和直接受到50拉德或以上原子辐射的人的患病率明显较高。在这项研究中，1，096名没有接受辐射剂量的人的患病率为17.9%，而美国系列的患病率为1.0%至4.0%。放射、检查方法、诊断标准和尸检选择中的偏倚似乎不能解释尸检中观察到的甲状腺癌的高频率。
Carcinoma of the thyroid at autopsy was found to be far more frequent in Japan than in any recorded American series. In 3,067 consecutive autopsies from the fixed population sample of the Japanese National Institute of Health-Atomic Bomb Casualty Commission Life-Span Study in Hiroshima and Nagasaki, 536 primary thyroid carcinomas were found—97% were occult papillary. The prevalence was significantly higher in women and those exposed to 50 rads or more of direct atomic radiation. The prevalence rate in the 1,096 persons in this study with no radiation dose whose entire thyroid gland was examined was 17.9% compared to 1.0% to 4.0% in the American series. Radiation, method of examination, diagnostic criteria, and bias in autopsy selection did not appear to explain the observed high frequency of thyroid carcinoma at autopsy.