Pathological change articular cartilage in of the mandibular head treated with immunosuppressant FK 506
Pathological change articular cartilage in of the mandibular head treated with immunosuppressant FK 506
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DOI：
10.14670/hh-19.15
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发表时间：
2004-01-01
影响因子：
2
通讯作者：
Yamamoto, T
中科院分区：
文献类型：
--
作者：
Ueno, T;Kagawa, T;Yamamoto, T
虽然一些报告已经记录了免疫抑制剂引起的骨质疏松症，但关节病理变化的确切机制仍有待澄清。本实验观察了5只SD大鼠连续28天给予免疫抑制剂FK 506后，下颌头关节软骨的病理变化。治疗组大鼠下颌骨头部的三维显微计算机断层扫描显示，与对照组大鼠相比，骨小梁体积显著减少。组织学观察显示关节软骨萎缩改变。免疫组化观察显示，与对照组相比，关节软骨细胞的增殖和分化明显降低（P < 0.05），而I型、II型和X型胶原抗体的表达则明显降低（P < 0.05）。
While several reports have documented immunosuppressant-induced osteoporosis, the exact mechanism of the pathological change of the joint remains to be clarified. In the present study, we have demonstrated the pathological change of the articular cartilage in the mandibular head of five Sprague-Dawley rats administered with the immunosuppressant FK 506 for 28 days. Three-dimensional micro-computed tomography of the mandibular heads in treated rats showed a significant decrease in trabecular bone volume compared to control rats. Histological observation revealed atrophic change of the articular cartilage. Immunohistological observation using anti-proliferative cell nuclear antibody (PCNA), type I, II, and type X collagen antibodies showed significantly decreased proliferation and differentiation of chondrocytes in the articular cartilage compared with the control group (p