Values of Cardio-Ankle Vascular Index (CAVI) between Amami Islands and Kagoshima Mainland Among Health Checkup Examinees
Values of Cardio-Ankle Vascular Index (CAVI) between Amami Islands and Kagoshima Mainland Among Health Checkup Examinees
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DOI：
10.5551/jat.6627
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发表时间：
2012-01-01
影响因子：
4.4
通讯作者：
Takezaki, Toshiro
中科院分区：
文献类型：
--
作者：
Hirasada, Kazuyo;Niimura, Hideshi;Takezaki, Toshiro
目的：利用心踝血管指数（CAVI）作为动脉硬度的替代指标，探讨日本奄美岛（Amami）和鹿儿岛（Kagoshima）高动脉硬度人群的患病率和地理差异。方法：招募奄美地区体检者4523人，大陆体检者440人，年龄40 ~ 69岁。高动脉僵硬的频率（CAVI >= 9.0）在地区之间进行了地理比较，并将两者的平均CAVI值与冠状动脉疾病危险因素较少的日本健康人群的平均值进行了比较。通过多元线性回归模型估计导致CAVI值升高的临床、生活方式和地区因素。结果：ami患者高动脉硬化发生率明显低于大陆患者。与健康的日本人相比，日本人在大美岛的平均CAVI值在男性中相似，而在女性中较低，但在大陆，男性和女性的CAVI值都较高。年龄、收缩压、甘油三酯、空腹血糖、高血压和糖尿病史与Amami的CAVI值升高呈正相关。在校正传统心血管危险因素后，与大陆相比，ami的区域因素与两性CAVI值升高呈负相关。结论：奄美居民的CAVI值明显低于大陆居民，提示环境或遗传因素可能改善奄美人群的动脉僵硬程度。
Aim: To investigate the prevalence and geographical variation of high arterial stiffness in groups from the Amami islands (Amami) and Kagoshima mainland (mainland), Japan, using the cardio-ankle vascular index (CAVI) as a surrogate marker of arterial stiffness.Methods: We recruited 4,523 health checkup examinees from Amami and 440 examinees from the mainland, with an age range of 40-69 years. The frequency of high arterial stiffness (CAVI >= 9.0) was geographically compared between the regions, and both mean CAVI values were compared with those of the healthy Japanese population with less risk factors for coronary artery disease. Clinical, lifestyle, and regional factors for increased CAVI values were estimated by the multiple linear regression model.Results: The frequency of high arterial stiffness on Amami was significantly lower than on the mainland. Mean CAVI values on Amami were similar in males and lower in females than in the healthy Japanese population, but those on the mainland were higher for both sexes. Age, systolic blood pressure, triglycerides, fasting blood glucose, and a history of hypertension and diabetes mellitus were positively related to increased CAVI values on Amami. The regional factor of Amami, compared with the mainland, was negatively related to increased CAVI values in both sexes after adjusting for traditional cardiovascular risk factors.Conclusion: CAVI values in Amami residents were significantly lower than in mainland residents, suggesting that environmental or genetic factors might have improved arterial stiffness in the Amami population.