Obesity-related plasma hemodilution and PSA concentration among men with prostate cancer
Obesity-related plasma hemodilution and PSA concentration among men with prostate cancer
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DOI：
10.1001/jama.298.19.2275
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发表时间：
2007-11-21
影响因子：
120.7
通讯作者：
Freedland, Stephen J.
中科院分区：
文献类型：
--
作者：
Banez, Lionel L.;Hamilton, Robert J.;Freedland, Stephen J.
最近的研究表明，肥胖男性的血清前列腺特异性抗原（PSA）浓度低于非肥胖男性。由于身体质量指数（BMI）较高的男性有较大的循环血浆容量，肥胖男性中较低的PSA浓度可能是由于血液稀释。目的探讨肥胖前列腺癌患者血液稀释度与PSA浓度的关系。设计、环境和参与者：对1988年至2006年因前列腺癌接受根治性前列腺切除术的男性进行回顾性研究，数据来自共享平等获取地区癌症医院（n=1373）、杜克前列腺中心（n=1974）和约翰霍普金斯医院（n= 10287）的数据库。采用调整临床病理特征的多元线性回归模型分析主要结局指标。BMI与校正后平均PSA浓度、平均血浆体积和校正后平均PSA质量（循环总PSA蛋白，以PSA浓度乘以血浆体积计算）之间的关联，通过确定趋势的P值来评估。结果在控制临床病理特征后，高BMI与高血浆容量（P < 0.001）和低PSA浓度（P < 0.001）显著相关
Context Recent studies have suggested that obese men have lower serum prostate-specific antigen (PSA) concentrations than nonobese men. Because men with higher body mass index (BMI) have greater circulating plasma volumes, lower PSA concentrations among obese men may be due to hemodilution.Objective To determine the association between hemodilution and PSA concentration in obese men with prostate cancer.Design, Setting, and Participants Retrospective study of men who underwent radical prostatectomy for prostate adenocarcinoma from 1988 to 2006, using data from the databases of the Shared Equal Access Regional Cancer Hospital (n=1373), Duke Prostate Center (n=1974), and Johns Hopkins Hospital (n=10 287). Multivariate linear regression models adjusting for clinicopathological characteristics were used to analyze the main outcome measures.Main Outcome Measures Associations between BMI and mean adjusted PSA concentrations, mean plasma volume, and mean adjusted PSA mass ( total circulating PSA protein, calculated as PSA concentration multiplied by plasma volume), assessed by determining P values for trend.Results After controlling for clinicopathological characteristics, higher BMI was significantly associated with higher plasma volume ( P < .001 for trend) and lower PSA concentrations ( P