Influences of NREM sleep on the activity of tonic vs. inspiratory phasic muscles in normal men.
Influences of NREM sleep on the activity of tonic vs. inspiratory phasic muscles in normal men.
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NREM 睡眠对正常男性强直与吸气相肌活动的影响。
DOI：
10.1152/jappl.1992.73.3.1058
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
White,DP
中科院分区：
文献类型：
--
作者：
Tangel,DJ;Mezzanotte,WS;Sandberg,EJ;White,DP
睡眠对人类咽部和其他呼吸肌的影响的研究表明，这些肌肉的活动可能会受到非快速眼动（NREM）睡眠的影响。这种可变的睡眠反应可能与肌肉激活模式（吸气阶段性与强直性）和气道中发生的外周事件有关。此外，这些肌肉在NREM睡眠期间对呼吸刺激的反应能力也可能不同。为了系统地研究NREM睡眠对呼吸肌活动的影响，我们研究了两个紧张性肌肉[腭肌张肌（TP）、咬肌（M）]和两个吸气时相性肌肉[颏舌肌（GG）、膈肌（D）]，并测量了这些肌肉在清醒和NREM睡眠期间对吸气阻力负荷（12 cmH2O.1 -1.s）的反应。7名正常男性受试者在一个晚上进行了研究，肌内电极放置在TP和GG和表面电极放置在D和M。连续记录睡眠阶段、吸气气流和上述四块肌肉的运动时间平均肌电图（EMG）。在NREM睡眠期间，两种紧张性肌肉的EMG均显著下降（P <0.05）[TP清醒，4.3 +/- 0.05（SE）任意单位，2期，1.1 +/- 0.2; 3/4期，1.0 +/- 0.2。咬肌清醒，4.8 ± 0.6; 2期，3.3 ± 0.5; 3/4期，3.1 ± 0.5]。另一方面，吸气时相肌（GG和D）的峰时相肌电图保持良好。（250字处删节）
Studies of sleep influences on human pharyngeal and other respiratory muscles suggest that the activity of these muscles may be affected by non-rapid-eye-movement (NREM) sleep in a nonuniform manner. This variable sleep response may relate to the pattern of activation of the muscle (inspiratory phasic vs. tonic) and peripheral events occurring in the airway. Furthermore, the ability of these muscles to respond to respiratory stimuli during NREM sleep may also differ. To systematically investigate the effect of NREM sleep on respiratory muscle activity, we studied two tonic muscles [tensor palatini (TP), masseter (M)] and two inspiratory phasic ones [genioglossus (GG), diaphragm (D)], also measuring the response of these muscles to inspiratory resistive loading (12 cmH2O.l-1.s) during wakefulness and NREM sleep. Seven normal male subjects were studied on a single night with intramuscular electrodes placed in the TP and GG and surface electrodes placed over the D and M. Sleep stage, inspiratory airflow, and moving time average electromyograph (EMG) of the above four muscles were continuously recorded. The EMG of both tonic muscles fell significantly (P less than 0.05) during NREM sleep [TP awake, 4.3 +/- 0.05 (SE) arbitrary units, stage 2, 1.1 +/- 0.2; stage 3/4, 1.0 +/- 0.2. Masseter awake, 4.8 +/- 0.6; stage 2, 3.3 +/- 0.5; stage 3/4, 3.1 +/- 0.5]. On the other hand, the peak phasic EMG of both inspiratory phasic muscles (GG and D) was well maintained.(ABSTRACT TRUNCATED AT 250 WORDS)