The role of infection in the development of non-valvular atrial fibrillation: Up-regulation of Toll-like receptor 2 expression levels on monocytes
The role of infection in the development of non-valvular atrial fibrillation: Up-regulation of Toll-like receptor 2 expression levels on monocytes
复制标题
DOI：
10.1016/j.jjcc.2008.09.008
复制
发表时间：
2009-02-01
影响因子：
2.5
通讯作者：
Tei, Chuwa
中科院分区：
文献类型：
--
作者：
Ichiki, Hitoshi;Orihara, Koji;Tei, Chuwa
许多研究表明，炎症可能参与了非瓣膜性心房的发病。房颤(AF)。然而，通过接触炎症是什么引起的，它一直是未知的。最近，我们报道了单核细胞表面Toll样受体2(TLR2)水平在病毒和细菌感染时显著上调，但在非感染性炎症状态下无明显上调。我们的目的是验证TLR2水平在非瓣膜性房颤患者中表达上调的假设。共有48名因导管消融住院的非瓣膜性房颤患者参加了这项研究。用流式细胞仪检测TLR2水平，并与正常对照组(n=24)进行比较。同时测定C-反应蛋白(CRP)和白介素6(IL-6)水平，并测定左心房。测量非瓣膜性房颤组的容量指数(LAVI)。结果表明，非瓣膜性房颤组TLR2水平显著高于对照组(中位数分别为4682和3866个位点/细胞；P<；0.01)。非瓣膜性房颤患者的IL-6水平显著高于对照组。然而，两组之间的CRP水平没有显著差异。在44例证实肺静脉隔离成功的房颤患者中，消融后1个月的LAVI显著降低(中位数，33.6vs.29.5ml/m(2)；P<；0.001)，但TLR2和IL-6水平无明显变化。我们的结果提示感染性炎症可能参与了非瓣膜性房颤的发病。(C)2008年日本心脏病学院。爱思唯尔爱尔兰有限公司出版。版权所有。
Many studies have suggested that inflammation may participate in the pathogenesis of non-valvular atrial. fibrillation (AF). However, it has been unknown by exposure to what the inflammation is caused. Recently, we reported that Toll-like receptor 2 (TLR2) level on monocytes was significantly up-regulated in viral and bacterial infections, but not in non-infectious inflammatory states. Our purpose was to test the hypothesis that expression of TLR2 levels may be up-regulated in patients with non-valvular AF A total of 48 consecutive patients with non-valvular AF who were hospitalized for catheter ablation were enrolled in this study. TLR2 levels were assayed by using flow-cytometric analysis and compared with volunteers in sinus rhythm (control group, n = 24). Additionally, C-reactive protein (CRP) and interleukin-6 (IL-6) levels were assayed, and the Left atrial. volume indexes (LAVI) in the non-valvular AF group were measured. The results demonstrated that TLR2 levels in the non-valvular AF group were significantly higher than in the control group (median, 4682 vs. 3866 sites/cell; P < 0.01). Moreover, non-valvular AF patients had significantly higher IL-6 levels than controls. However, there was no significant difference in CRP Levels between the two groups. It was observed in 44 AF patients, in whom pulmonary vein isolation was confirmed to be successful, that the LAVI significantly diminished 1 month after ablation (median, 33.6 vs. 29.5 ml/m(2); P < 0.001), but not the TLR2 and IL-6 levels. Our results implied that an infectious inflammation may participate in the pathogenesis of non-valvular AF. (c) 2008 Japanese College of Cardiology. Published by Elsevier Ireland Ltd. All rights reserved.