Fabrication of 3-dimensional cellular constructs via microstereolithography using a simple, three-component, poly(ethylene glycol) acrylate-based system.
Fabrication of 3-dimensional cellular constructs via microstereolithography using a simple, three-component, poly(ethylene glycol) acrylate-based system.
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DOI：
10.1021/bm3015736
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发表时间：
2013-01
影响因子：
6.2
通讯作者：
S. Leigh;Hamish T. J. Gilbert;Ian A. Barker;J. Becker;S. Richardson;J. Hoyland;J. Covington;A. P. Dove
中科院分区：
文献类型：
--
作者：
S. Leigh;Hamish T. J. Gilbert;Ian A. Barker;J. Becker;S. Richardson;J. Hoyland;J. Covington;A. P. Dove
报道了一种制备适用于三维（3D）微立体光刻的无阻聚剂和无溶剂树脂的新方法。使用示例性的聚（乙二醇）基树脂，在X，Y和Z平面中的功能的控制被证明，使得复杂的结构可以被制造。在制造的支架上培养的人间充质干细胞在7天的评估期间保持活力，增殖率与在组织培养聚苯乙烯上观察到的增殖率相当。这些数据表明，这种新颖而简单的方法适用于生产用于组织工程和再生医学应用的3D支架。
A novel method for the production of inhibitor- and solvent-free resins suitable for three-dimensional (3D) microstereolithography is reported. Using an exemplar poly(ethylene glycol)-based resin, the control of features in the X, Y, and Z planes is demonstrated such that complex structures can be manufactured. Human mesenchymal stem cells cultured on the manufactured scaffolds remained viable during the 7 day assessment period, with proliferation rates comparable to those observed on tissue culture polystyrene. These data suggest that this novel, yet simple, method is suitable for the production of 3D scaffolds for tissue engineering and regenerative medicine applications.