Minimum energy single-shock internal atrial defibrillation in sheep.
Minimum energy single-shock internal atrial defibrillation in sheep.
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绵羊最小能量单次电击心房除颤。
DOI：
10.1023/b:jice.0000019266.09648.f6
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Wolf,PatrickD
中科院分区：
文献类型：
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作者：
Goodman,AmyM;Clyde,MerliseA;Burdick,DonaldS;Idriss,SalimF;Wolf,PatrickD
耐受良好的内部心房除颤电击必须低于疼痛阈值，据估计疼痛阈值小于1焦耳。通过在除颤剂量-反应曲线的低端提供电击，使低能量心房除颤成为可能。我们研究了绵羊的低能量除颤，以检验使心房除颤10%时间（ED 10）的能量小于1焦耳的假设。用快速起搏诱发慢性心房颤动（AF）的方法，测定了7只绵羊的ED_（10）。从冠状窦（CS）向上级腔静脉（SVC）输送低能量除颤电击，然后使用逻辑回归计算ED 10和ED 50（除颤心房50%时间的能量）。ED 10与ED 50的平均比值为0.50，表明平均而言，ED 10等于ED 50的一半。ED 10冲击的能量范围为1.2至5.8焦耳。这些结果表明，无痛单次电击低能量除颤可能不可行。
Well-tolerated internal atrial defibrillation shocks must be below the pain threshold, which has been estimated to be less than 1 Joule. Defibrillation of the atria with low energy is made possible by delivering shocks at the low end of the defibrillation dose-response curve. We studied low-energy defibrillation in sheep to test the hypothesis that the energy that defibrillates the atria 10% of the time (ED10) is less than 1 Joule. The ED10 was estimated in seven sheep with rapid pacing induced chronic atrial fibrillation (AF). Low-energy defibrillation shocks were delivered from coronary sinus (CS) to superior vena cava (SVC) and the ED10 and ED50 (energy that defibrillates the atria 50% of the time) were then calculated using logistic regression. The mean ratio of ED10 to ED50 was 0.50, indicating that on average, the ED10 was equal to half of the ED50. ED10 shocks had energies ranging from 1.2 to 5.8 Joules. These results suggest that painless single-shock low-energy defibrillation may not be feasible.