The synergetic antibacterial activity of Ag islands on ZnO (Ag/ZnO) heterostructure nanoparticles and its mode of action.
The synergetic antibacterial activity of Ag islands on ZnO (Ag/ZnO) heterostructure nanoparticles and its mode of action.
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DOI：
10.1016/j.jinorgbio.2013.10.004
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发表时间：
2014
影响因子：
3.9
通讯作者：
Yi Zhang;Xingjie Gao;Lei Zhi;Xin Liu;Wei Jiang;Yanhua Sun;Jie Yang
中科院分区：
文献类型：
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作者：
Yi Zhang;Xingjie Gao;Lei Zhi;Xin Liu;Wei Jiang;Yanhua Sun;Jie Yang
银纳米颗粒(NPs)具有良好的抗菌活性，而氧化锌是一种很有前途的光催化剂。虽然已有报道表明银/氧化锌异质结构纳米颗粒的光催化活性优于纯的氧化锌纳米颗粒，但现有的抗菌活性比较都是在银掺杂的氧化锌纳米颗粒和纯银纳米颗粒(或纯氧化锌纳米颗粒)之间进行的，仍然存在争议。采用两步法制备银/氧化锌HNPs，并对其进行了表征。与单纯的银/氧化锌纳米粒混合物相比，合成的银/氧化锌纳米粒对大肠埃希菌(ATCC 25922)和金黄色葡萄球菌(ATCC 25923)的抗菌活性有了很大的提高，尤其是当Ag含量为5.0wt.%时。这种增强主要是由于银/氧化锌HNPs引起的反应性氧化物种(尤其是超氧化物)的明显增加和对质粒DNA的损伤。
Sliver nanoparticles (NPs) possess wonderful antibacterial activity while ZnO is a promising photocatalyst. Although it has been reported that the photocatalytic activity of Ag/ZnO heterostructure nanoparticles (HNPs) was better than that of pure ZnO NPs, the existing comparisons on their antibacterial activity were all taken between Ag-doped ZnO HNPs and pure Ag NPs (or pure ZnO NPs), and were still controversial. Ag islands on ZnO, another type of Ag/ZnO HNPs, were synthesized by a two-step preparation and characterized in this work. The antibacterial activity of as-synthesized Ag/ZnO HNPs, especially with 5.0 wt.% of Ag, againstEscherichia coli(ATCC 25922) andStaphylococcus aureus(ATCC 25923) was enhanced greatly in contrast with that of the simple mixture of Ag and ZnO NPs. The enhancement was found to be mainly due to the obvious increase in the reactive oxidative species (especially superoxide) and the increased damage to plasmid DNA induced by Ag/ZnO HNPs.