New Approach to Treatment of Shock—Restitution of Vasoreactivity
New Approach to Treatment of Shock—Restitution of Vasoreactivity
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DOI：
10.1097/00024382-200208000-00017
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发表时间：
2002-08
期刊：
影响因子：
3.1
通讯作者：
K. Zhao;Xuliang Huang;Jie Liu;Qiaobing Huang;Chunhua Jin;Yong Jiang;Jian-qiu Jin;Gui-ling Zhao-
中科院分区：
文献类型：
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作者：
K. Zhao;Xuliang Huang;Jie Liu;Qiaobing Huang;Chunhua Jin;Yong Jiang;Jian-qiu Jin;Gui-ling Zhao-
我们的目的是观察恢复血管反应剂对严重休克的治疗效果。在大鼠中复制失血性休克（HS）模型，并测试了HS中斜方肌小动脉对去甲肾上腺素（NE）的反应。测量小动脉的直径、血流速度和体积流量以及平均动脉压（MAP）。给予恢复血管反应剂（ATP敏感钾通道抑制剂格列苯脲、氧自由基清除剂替隆）治疗后观察疗效。 HS后2小时，小动脉血管反应性显着降低，NE阈值增加15倍。经恢复剂(RA)治疗后，大鼠血管低反应性明显恢复，注射多巴胺后MAP升高水平分别是NS组和DMSO组的1.8倍和1.9倍。流血回输后2h观察期内，RA组全身血压维持在100mmHg以上，小动脉容积流量较NS治疗组增加2倍。 RA治疗组的平均生存时间也分别比NS治疗组和DMSO治疗组长1.8倍和1.6倍。本发明的血管反应恢复剂能够恢复严重失血性休克时较低的血管反应性，具有良好的抗休克作用。
Our objective was to observe the therapeutic effect of restituting vasoreactivity agent in severe shock. A hemorrhagic shock (HS) model was reproduced in rat and the response of arterioles of spinotrapezius muscle to norepinephrine (NE) in HS was tested. The diameter, blood velocity, and volumetric flow in arteriole, and the mean arterial pressure (MAP) were measured. The therapeutic effect was observed after the treatment of restituting vasoreactivity agent (glybenclamide—an inhibitor of ATP sensitive potassium channel, and tiron—an oxygen free radical scavenger). The arteriolar vasoreactivity was significantly reduced with 15 fold increase of NE threshold 2 h post HS. After treated with restituting agent(RA), the vascular hyporeactivity of rat was apparently recovered, and the increased level of MAP following injection of dopamine was 1.8 times and 1.9 times more than that in NS-treated and DMSO-treated group respectively. After reinfusion of shed blood, the value of systemic blood pressure maintained more than 100mmHg and volumetric flow in arterioles in RA group were 2 times more than those in NS treated group within the 2h observation periods. The average survival time in RA treated group was also 1.8 times and 1.6 times longer than that in NS-treated and DMSO-treated group respectively. The restituting vasoreactivity agent is able to recover the lower vasoreactivity with excellent anti-shock effect in severe hemorrhagic shock.