Late-occurring stroke among long-term survivors of childhood leukemia and brain tumors: A report from the childhood cancer survivor study
Late-occurring stroke among long-term survivors of childhood leukemia and brain tumors: A report from the childhood cancer survivor study
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DOI：
10.1200/jco.2006.07.2884
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发表时间：
2006-11-20
影响因子：
45.3
通讯作者：
Oeffinger, Kevin C.
中科院分区：
文献类型：
--
作者：
Bowers, Daniel C.;Liu, Yan;Oeffinger, Kevin C.
研究目的：本报告调查了5年以上儿童白血病和脑肿瘤幸存者中风的发病率和危险因素，确定了白血病幸存者自报迟发性中风的首次发生率（n = 4，828），脑肿瘤幸存者（n = 1，871），以及癌症幸存者兄弟姐妹随机样本的对照组（n = 3，846）。治疗暴露中风的相对风险（RR）和95%置信区间（Cls）进行了检查，通过多变量analysis.ResultsThirty-seven白血病幸存者和63脑肿瘤幸存者报告了迟发性中风。白血病幸存者迟发性卒中的发生率为57.9/10万人-年（95%CI，41.2 - 78.7）。与同胞对照组相比，白血病幸存者中风的BR为6.4（95%CI，3.0至13.8，P = 50戈伊CRT。ConclusionSurvivors of childhood leukemia and brain tumors，特别是那些接受CRT治疗的脑肿瘤患者，剂量大于30戈伊，中风的风险增加。
PurposeThis report examines the incidence of and risk factors for strokes that occur in >= 5-year survivors of childhood leukemia and brain tumors.Patients and MethodsThe rate of first occurrence of self-reported late-occurring strokes was determined for leukemia survivors (n = 4,828), brain tumor survivors (n = 1,871), and a comparison group of a random sample of cancer survivor siblings (n = 3,846). Relative risks (RRs) and 95% confidence intervals (Cls) of stroke by treatment exposures were examined by multivariate analyses.ResultsThirty-seven leukemia survivors and 63 brain tumor survivors reported a late-occurring stroke. The rate of late-occurring stroke for leukemia survivors was 57.9 per 100,000 person-years (95% Cl, 41.2 to 78.7). The BR of stroke for leukemia survivors compared with the sibling comparison group was 6.4 (95% Cl, 3.0 to 13.8, P = 50 Gy CRT.ConclusionSurvivors of childhood leukemia and brain tumors, particularly those with brain tumors treated with CRT at doses of greater than 30 Gy, are at an increased risk of stroke.