TRIM22: A Diverse and Dynamic Antiviral Protein.
TRIM22: A Diverse and Dynamic Antiviral Protein.
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DOI：
10.1155/2012/153415
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Barr SD
中科院分区：
文献类型：
--
作者：
Hattlmann CJ;Kelly JN;Barr SD
tripartite motif （TRIM）蛋白家族是一个进化上古老的蛋白群，在无脊椎动物和脊椎动物物种中都发现了同源物。人类TRIM22就是这样一种蛋白质，它具有动态的进化史，包括基因扩增、基因丢失和强烈的正选择特征。迄今为止，TRIM22已被证明可以限制许多病毒的复制，包括脑心肌炎病毒（EMCV）、乙型肝炎病毒（HBV）和人类免疫缺陷病毒1型（HIV-1）。此外，TRIM22还参与细胞分化和增殖，并可能在某些癌症和自身免疫性疾病中发挥作用。本文综述了目前对TRIM22结构和功能的认识。
The tripartite motif (TRIM) family of proteins is an evolutionarily ancient group of proteins with homologues identified in both invertebrate and vertebrate species. Human TRIM22 is one such protein that has a dynamic evolutionary history that includes gene expansion, gene loss, and strong signatures of positive selection. To date, TRIM22 has been shown to restrict the replication of a number of viruses, including encephalomyocarditis virus (EMCV), hepatitis B virus (HBV), and human immunodeficiency virus type 1 (HIV-1). In addition, TRIM22 has also been implicated in cellular differentiation and proliferation and may play a role in certain cancers and autoimmune diseases. This comprehensive paper summarizes our current understanding of TRIM22 structure and function.