Origin of Primary Sensory Neurons Innervating the Buccal Stretch Receptor
Origin of Primary Sensory Neurons Innervating the Buccal Stretch Receptor
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DOI：
10.1177/00220345990780010601
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发表时间：
1999-01
影响因子：
7.6
通讯作者：
T. Yamamoto;M. Onozuka;S. Nagasaki;K. Watanabe;S. Ozono
中科院分区：
文献类型：
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作者：
T. Yamamoto;M. Onozuka;S. Nagasaki;K. Watanabe;S. Ozono
支配口面部机械感受器的初级感觉神经元的胞体位于三叉神经节或三叉神经中脑核。颊侧牵张感受器（buccal stretch receptor，BSR）是啮齿类动物下颌骨中的一种机械感受器，近年来被认为是下颌骨位置的信号传递者。支配该受体的初级传入神经元的位置尚不清楚。为研究大鼠BSR传入神经元的胞体，我们将小麦胚芽凝集素-辣根过氧化物酶（WGA-HRP）应用于供应BSR的颊神经分支的断端近端。在同侧三叉神经节的后外侧部分观察到HRP标记的细胞体。在对侧三叉神经节和脑干中均未发现。所有标记细胞胞体均呈椭圆形或圆形，与假单极神经元相似。标记胞体的平均直径为25.5 ~ 52.5 μm，其中小胞体（≤ 30 μm）占8.8%，中胞体（31 ~ 40 μm）占54.9%，大胞体（≥ 41 μm）占36.3%。在WGA-HRP标记的分支中，78.5%的有髓神经纤维终止于BSR，且纤维直径较大，表明大部分中、大型HRP标记细胞体为BSR传入纤维。从这些结果和该受体的个体发生起源，这表明，BSR分化的机械感受器在口腔粘膜或咀嚼肌筋膜。
The primary sensory neurons innervating mechanoreceptors in oro-facial regions have their cell bodies in either the trigeminal ganglion or the mesencephalic nucleus of the trigeminal nerve. The buccal stretch receptor (BSR), a type of mechanoreceptor in the jaw of rodents, has recently been recognized as signaling the position of the mandible. The location of the primary afferent neurons innervating this receptor is unknown. To investigate the cell bodies of the BSR afferent neurons in rats, we applied wheat germ agglutinin-horseradish peroxidase (WGA-HRP) to the proximal stump of the severed nerve branch of the buccal nerve that supplied the BSR. HRP-labeled cell bodies were observed in the posterolateral portion of the ipsilateral trigeminal ganglion. None was found in the contralateral trigeminal ganglion or in the brainstem. All labeled cell bodies were oval or round and closely resembled pseudo-unipolar neurons. The mean diameter of the labeled somata ranged between 25.5 and 52.5 μm, with small (≤ 30 μm), medium (from 31 to 40 μm), and large somata (≥ 41 μm) accounting for 8.8%, 54.9%, and 36.3%, respectively. Among the myelinated nerve fibers in the branch in which WGA-HRP was applied, 78.5% terminated in the BSR and had larger fiber diameters than the rest, indicating that most of the medium and large HRP-labeled cell bodies were BSR afferents. From these results and the ontogenetic origin of this receptor, it is suggested that the BSR differentiated from the mechanoreceptors in the oral mucosa or the fascia of masticatory muscles.