A simplified [11C]phosgene synthesis
A simplified [11C]phosgene synthesis
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DOI：
10.1016/j.tetlet.2009.11.011
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发表时间：
2010-01-13
影响因子：
1.8
通讯作者：
Dolle, Frederic
中科院分区：
文献类型：
--
作者：
Bramoulle, Yann;Roeda, Dirk;Dolle, Frederic
本文介绍了一种新的用于生产PET放射化学标记剂[C-11]光气的流通系统。将回旋加速器产生的[C-11] CH 4与Cl-2混合，并通过使混合物在510 ℃下通过空石英管将其转化为[C-11] CCl 4。流出物被引导通过Sb填充的保护装置，该保护装置取出Cl-2，然后在没有故意添加O-2的情况下，在750 ℃下通过第二个空石英管，以30-35%的放射化学产率产生[C-11]光气。(C)2009爱思唯尔有限公司保留所有权利。
A new flow-through system for the production of [C-11]phosgene, a versatile labelling agent in radiochemistry for PET, is described. Cyclotron-produced [C-11]CH4 is mixed with Cl-2 and converted into [C-11]CCl4 by passing the mixture through an empty quartz tube at 510 degrees C. The Outflow is directed through a Sb-filled guard that takes Out Cl-2 and then, without intentional O-2 addition, through a second empty quartz tube at 750 degrees C, giving rise to [C-11]phosgene in 30-35% radiochemical yield. (C) 2009 Elsevier Ltd. All rights reserved.