Genome rearrangements and pervasive meiotic drive cause hybrid infertility in fission yeast
Genome rearrangements and pervasive meiotic drive cause hybrid infertility in fission yeast
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DOI：
10.7554/elife.02630
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发表时间：
2014-06-24
期刊：
影响因子：
7.7
通讯作者：
Malik, Harmit Singh
中科院分区：
文献类型：
--
作者：
Zanders, Sarah E.;Eickbush, Michael T.;Malik, Harmit Singh
杂种不育是两个最近分化的物种之间最早的合子后隔离机制之一。在这里，我们确定了两个最近分化的裂殖酵母物种粟酒裂殖酵母和S。红茶菌交配形成能有效完成减数分裂但几乎不产生能存活的配子的能存活的杂交二倍体。我们发现染色体重排和相关的重组缺陷是杂种不育的主要但不是唯一的原因。至少三个不同的减数分裂驱动等位基因，每个S上一个。红茶菌染色体通过引起非随机孢子死亡而独立地导致杂种不育。这些驱动基因座中的两个通过染色体易位连接，因此构成了一种新型的成对减数分裂驱动复合体。我们的研究揭示了生育的多重障碍会多快出现。此外，它提供了进一步的支持模型，其中遗传冲突，如减数分裂驱动等位基因，可以驱动物种形成。
Hybrid sterility is one of the earliest postzygotic isolating mechanisms to evolve between two recently diverged species. Here we identify causes underlying hybrid infertility of two recently diverged fission yeast species Schizosaccharomyces pombe and S. kambucha, which mate to form viable hybrid diploids that efficiently complete meiosis, but generate few viable gametes. We find that chromosomal rearrangements and related recombination defects are major but not sole causes of hybrid infertility. At least three distinct meiotic drive alleles, one on each S. kambucha chromosome, independently contribute to hybrid infertility by causing nonrandom spore death. Two of these driving loci are linked by a chromosomal translocation and thus constitute a novel type of paired meiotic drive complex. Our study reveals how quickly multiple barriers to fertility can arise. In addition, it provides further support for models in which genetic conflicts, such as those caused by meiotic drive alleles, can drive speciation.