Relationship of P300 single-trial responses with reaction time and preceding stimulus sequence
Relationship of P300 single-trial responses with reaction time and preceding stimulus sequence
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DOI：
10.1016/j.ijpsycho.2005.10.015
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发表时间：
2006-08-01
影响因子：
3
通讯作者：
Muller, Kiti
中科院分区：
文献类型：
--
作者：
Holm, Anu;Ranta-aho, Perttu O.;Muller, Kiti
研究了单次试验P300反应与反应时间和前一个刺激序列的关系。采用基于贝叶斯估计和线性建模的子空间正则化方法对单次试验响应进行估计。将单次试验法的结果与平均法的结果进行比较。两种方法均表明，在快速反应时，P300的潜伏期较短，振幅较大。与前面有少量标准音调的目标音调相比，前面有大量标准音调的目标音调的P300延迟时间更短。刺激序列对P300振幅的影响只有在常规平均分析时才有统计学意义。对标准差的深入分析表明，P300单次试验潜伏期的可变性可以解释两种方法之间的差异。具体而言，回归分析表明，潜伏期与前一个标准音调的数量呈负相关，与反应时间呈正相关，而P300振幅与前一个标准刺激的数量呈正相关，与反应时间呈负相关。对单次试验响应的分析提供了关于P300分量的行为的信息，这是用常规平均法丢失的。本研究中使用的方法独立于主观决策，可用于客观地模拟P300组件动态行为的变化。(c) 2005 Elsevier B.V.版权所有
Variation of single-trial P300 responses was studied both in relation to reaction times and to the preceding stimulus sequence in an auditory oddball paradigm. Single-trial responses were estimated with the Subspace regularization method that is based on Bayesian estimation and linear modeling. The results of the single-trial method were compared to those of averaging. Both methods showed that the latency of the P300 was shorter and its amplitude larger for faster than slower reaction times. The P300 latency was shorter for target tones that were preceded by a large number of standard tones compared to those preceded by a small number of standard tones. The P300 amplitude was statistically significantly affected by the stimulus sequence only when analyzed with conventional averaging. In-depth analysis of standard deviations showed that the variability of the P300 single-trial latencies could explain the differences between the two methods. Specifically, the regression analysis showed that the latency correlated negatively with the number of preceding standard tones and positively with the reaction time, whereas the P300 amplitude correlated positively with the number of the preceding standard stimuli and negatively with the reaction time. The analysis of the single-trial responses gives information about the behavior of the P300 component that is lost with conventional averaging. The method used in this study is independent of Subjective decision making and can be used to model changes in the dynamical behavior of the P300 component objectively. (c) 2005 Elsevier B.V. All rights reserved.