HOX Gene Expression
HOX Gene Expression
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HOX基因表达
DOI：
10.1007/978-0-387-68990-6_4
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Ferrier D
中科院分区：
文献类型：
--
作者：
Ferrier D
HOX基因簇一直是发育生物学中最突出的范例之一。这源于发现这些基因都包含保守的同源框基序，以及同源基因在生物体的发育过程中以广泛同源的方式运行，这一发现令人兴奋不已，就像苍蝇和脊椎动物一样在系统发育上分布广泛。基于同源盒的基因与它们在苍蝇和脊椎动物中特定的基因组组织之间的序列相似性，立即暗示了HOX基因簇通过串联复制的一种特定进化模式，更有趣的是，对簇组织的功能限制以保持共线性。这一总体情况仍然适用，但近年来，随着从更广泛的动物门选择中获得数据，我们对集群组织限制的性质和程度的理解有所改变。
The Hox gene clusters have been one of the most prominent paradigms within Developmental Biology. This stems from the great excitement that surrounded the discovery that the genes all contained the conserved homeobox motif and that the homologous genes were operating in broadly homologous ways in the development of organisms as phylogenetically widespread as flies and vertebrates. The sequence similarity between the genes based on the homeobox, and their specific genomic organization in both flies and vertebrates, immediately implied a particular mode of evolution of the Hox gene cluster by tandem duplication and, more intriguingly, a functional constraint on the organization of the cluster to conserve colinearity. This general picture still holds true, but our understanding of the nature and extent of the constraints on cluster organization have been modified in recent years as data has become available from a much wider selection of animal phyla.