Dynamical Rheological Properties of In-Silico Epithelial Tissue by Vertex Models.
Dynamical Rheological Properties of In-Silico Epithelial Tissue by Vertex Models.
复制标题
通过顶点模型模拟上皮组织的动态流变特性。
DOI：
10.1007/978-3-030-43195-2_53
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Ishimoto Y.
中科院分区：
文献类型：
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作者：
Toyoshima T.;Ishimoto Y.
包括人类在内的许多生物系统都是由各种细胞组成的。此外，特定类型的细胞聚集在一起形成组织，器官被组织为多个组织的集合体。构成器官的组织之一是上皮组织。上皮组织由上皮细胞组成，机体内外几乎所有表面都覆盖有上皮组织，其中许多是单层的。许多研究人员已经开发了表达上皮组织形态发生的数学模型。其中一种模型，细胞顶点模型[1]通过细胞的多边形近似讨论组织生长，但它没有考虑细胞边界的曲率。 Ishimoto等人发展了气泡顶点模型[2]，将曲率引入模型中并研究了上皮组织的形态。在本研究中，我们重点研究上皮组织的两种数学模型：细胞顶点模型和气泡顶点模型。我们通过模拟分析模型的流变特性，旨在找到与实际粘弹性上皮组织的对应关系。
Many biological systems including humans are made up of various cells. In addition, cells of a specific type gather together to form tissues, and organs are organized as an aggregate of multiple tissues. One of the tissues constituting organs is epithelial tissue. Epithelial tissue is composed of epithelial cells, and almost all the surfaces inside and outside the body is covered with epithelial tissue, many of which are monolayered. Mathematical models expressing morphogenesis of epithelial tissue have been developed by many researchers. One of the models, the cell vertex model [1] discusses tissue growth through polygonal approximation of cells, but it does not take into account the curvature of cell boundaries. Ishimotoet al., developed the bubbly vertex model [2] introducing the curvature into the model and studied the morphology of the epithelial tissue.In this study, we focus on two mathematical models of epithelial tissue: the cell vertex model and the bubbly vertex model. We analyze the rheological properties of the models by simulation and aim at finding a correspondence with actual viscoelastic epithelial tissues.