Adrenal-dependent change in vascular reactivity in stroke-prone spontaneously hypertensive rats.
Adrenal-dependent change in vascular reactivity in stroke-prone spontaneously hypertensive rats.
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易发生中风的自发性高血压大鼠血管反应性的肾上腺依赖性变化。
DOI：
10.1161/01.hyp.12.4.388
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Webb,RC
中科院分区：
文献类型：
--
作者：
Bruner,CA;Webb,RC
易卒中自发性高血压大鼠（SHRSP）的尾动脉对去甲肾上腺素反应性振荡收缩。这种类型的振荡行为不发生在血压正常的Wistar-Kyoto大鼠（WKY）的尾动脉。我们已经表明，去甲肾上腺素诱导的振荡活动和高血压的性状在SHRSP中是遗传相关的，这表明振荡活动是导致该品系高血压的主要血管异常。在本实验中，两种方法被用来测试的假设，肾上腺盐皮质激素调节这种遗传决定的血管异常在SHRSP的表达。首先，在实验前3周接受双侧肾上腺切除术的SHRSP中确定肾上腺切除术对血压和振荡活动的影响。第二，在1）没有振荡活动遗传背景的大鼠（WKY）和2）SHRSP x WKY的后代（F1大鼠）中测定醋酸脱氧皮质酮（DOCA）-盐处理对血压和振荡活动的影响。将来自所有大鼠的螺旋切割的尾动脉条固定在隔离的组织浴中用于等长力记录。将血管暴露于各浓度的去甲肾上腺素（6 x 10（-10）至6 x 10（-6）M）20分钟。振荡活动定义为去甲肾上腺素孵育最后10分钟期间发生的所有振荡的阶段性收缩幅度之和。肾上腺切除显著降低SHRSP的血压和振荡活动。（250字处删节）
Tail arteries from stroke-prone spontaneously hypertensive rats (SHRSP) exhibit oscillatory contractions in response to norepinephrine. This type of oscillatory behavior does not occur in tail arteries from normotensive Wistar-Kyoto rats (WKY). We have shown that the traits of norepinephrine-induced oscillatory activity and high blood pressure are genetically associated in SHRSP, suggesting that oscillatory activity is a primary vascular abnormality that contributes to hypertension in this strain. In the present experiments, two approaches were used to test the hypothesis that adrenal mineralocorticoids modulate expression of this genetically determined vascular abnormality in SHRSP. First, the effect of adrenalectomy on blood pressure and oscillatory activity was determined in SHRSP that underwent bilateral adrenalectomy 3 weeks before experimentation. Second, the effect of deoxycorticosterone acetate (DOCA)-salt treatment on blood pressure and oscillatory activity was determined in 1) rats with no genetic background for oscillatory activity (WKY) and 2) progeny of SHRSP x WKY (F1 rats). Helically cut tail artery strips from all rats were mounted in isolated tissue baths for isometric force recording. Vessels were exposed to norepinephrine (6 x 10(-10) to 6 x 10(-6) M) for 20 minutes at each concentration. Oscillatory activity was defined as the sum of the phasic contractile amplitudes for all oscillations occurring during the final 10 minutes of norepinephrine incubation. Adrenalectomy markedly decreased blood pressure and oscillatory activity in SHRSP.(ABSTRACT TRUNCATED AT 250 WORDS)