Perspectives of vaccination in Chagas disease revisited
Perspectives of vaccination in Chagas disease revisited
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DOI：
10.1590/s0074-02762009000900036
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发表时间：
2009-07-01
期刊：
影响因子：
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通讯作者：
Camargo, Erney Plessmann
中科院分区：
文献类型：
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作者：
Camargo, Erney Plessmann
对 30 年前和今天的恰加斯病疫苗的前景进行了比较。抗原和佐剂有所改善，但后勤问题仍然存在。尚未生产出灭菌疫苗，也尚未开发出慢性查加斯病的动物模型。病媒控制已取得成功，南美锥虫病发病率已停止。巴西目前还没有适合接种疫苗的人群。如果我们这样做了，我们就不知道如何在短时间内评估疫苗接种的成功与否。目前疫苗似乎并不重要。然而，科学原因和对未来的不确定性建议继续寻找疫苗。
The perspectives for a Chagas Disease vaccine 30 years ago and today are compared. Antigens and adjuvants have improved, but logistic problems remain the same. Sterilizing vaccines have not been produced and animal models for chronic Chagas have not been developed. Vector control has been successful and Chagas incidence has come to a halt. We do not have a population candidate to vaccination now in Brazil. And if we had, we would not know how to evaluate the success of vaccination in a short time period. A vaccine may not seem important at the moment. However, scientific reasons and incertitudes about the future recommend that a search for a vaccine be continued.