Meta-analysis of telomere length in 19 713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect
Meta-analysis of telomere length in 19 713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect
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DOI：
10.1038/ejhg.2012.303
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发表时间：
2013-10-01
影响因子：
5.2
通讯作者：
Boomsma, Dorret I.
中科院分区：
文献类型：
--
作者：
Broer, Linda;Codd, Veryan;Boomsma, Dorret I.
端粒长度(TL)与衰老和死亡率有关，但个体差异也受到遗传因素的影响，先前的研究报告遗传率估计在34%到82%之间。在这里，我们调查了遗传度、遗传方式和出生时父母年龄对TL的影响，研究了六个大型的独立队列研究，总共有19713名参与者。TL遗传度的荟萃分析估计为0.70(95%可信区间0.64-0.76)，并基于双胞胎和其他家庭成员高度相似的结果模式。我们观察到母子关系(r=0.42；P值=3.60x10(-61))强于父子关系(r=0.33；P值=7.01x10(-5))，并且与子代出生时的父亲年龄(β=0.005；P值=7.01x10(-5))呈显著正相关。有趣的是，配偶之间的TL存在显著且相当显著的相关性(r=0.25；P值=2.82x10(-30))，这种相关性在年龄较大的配偶对(平均年龄=55岁；r=0.31；P值=4.27x10(-23))中表现得比年轻夫妇(平均年龄)更强
Telomere length (TL) has been associated with aging and mortality, but individual differences are also influenced by genetic factors, with previous studies reporting heritability estimates ranging from 34 to 82%. Here we investigate the heritability, mode of inheritance and the influence of parental age at birth on TL in six large, independent cohort studies with a total of 19 713 participants. The meta-analysis estimate of TL heritability was 0.70 (95% CI 0.64-0.76) and is based on a pattern of results that is highly similar for twins and other family members. We observed a stronger mother-offspring (r = 0.42; P-value = 3.60 x 10(-61)) than father-offspring correlation (r = 0.33; P-value = 7.01 x 10(-5)), and a significant positive association with paternal age at offspring birth (beta = 0.005; P-value = 7.01 x 10(-5)). Interestingly, a significant and quite substantial correlation in TL between spouses (r = 0.25; P-value = 2.82 x 10(-30)) was seen, which appeared stronger in older spouse pairs (mean age >= 55 years; r = 0.31; P-value = 4.27 x 10(-23)) than in younger pairs (mean age