Neuroscience and Biobehavioral Reviews Review from the Ventral to the Dorsal Striatum: Devolving Views of Their Roles in Drug Addiction
Neuroscience and Biobehavioral Reviews Review from the Ventral to the Dorsal Striatum: Devolving Views of Their Roles in Drug Addiction
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通讯作者：
B. Everitt;T. Robbins
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作者：
B. Everitt;T. Robbins
我们重新审视了我们的假设，即药物成瘾可以被视为从最初的自愿药物使用到习惯性药物使用和最终强迫性药物使用的一系列过渡的终点。我们特别关注的过渡，在纹状体控制药物寻求行为的基础上，这些过渡，因为功能异质性的纹状体是一个关键领域的安凯利的研究兴趣和一个，她作出了巨大的贡献。我们还讨论了假设，根据最近的数据，出现了一个强迫性的药物寻求习惯，反映了一个转变，背侧纹状体控制行为和受损的前额皮质抑制控制机制。我们进一步讨论了强迫性药物使用的脆弱性方面，特别是冲动的影响。在写这篇评论时，我们承认一位杰出的科学家和一位亲爱的私人朋友的过早死亡。
We revisit our hypothesis that drug addiction can be viewed as the endpoint of a series of transitions from initial voluntarily drug use to habitual, and ultimately compulsive drug use. We especially focus on the transitions in striatal control over drug seeking behaviour that underlie these transitions since functional heterogeneity of the striatum was a key area of Ann Kelley's research interests and one in which she made enormous contributions. We also discuss the hypothesis in light of recent data that the emergence of a compulsive drug seeking habit both reflects a shift to dorsal striatal control over behaviour and impaired prefontal cortical inhibitory control mechanisms. We further discuss aspects of the vulnerability to compulsive drug use and in particular the impact of impulsivity. In writing this review we acknowledge the untimely death of an outstanding scientist and a dear personal friend.