Cellular localisation of a water-soluble fullerene derivative
Cellular localisation of a water-soluble fullerene derivative
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DOI：
10.1016/s0006-291x(02)00445-x
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发表时间：
2002-05-31
影响因子：
3.1
通讯作者：
Larroque, C
中科院分区：
文献类型：
--
作者：
Foley, S;Crowley, C;Larroque, C
富勒烯是一类新型化合物，在生物学和医学领域具有潜在用途，人们在了解它们与各种生物系统的相互作用方面取得了许多见解。然而，它们与有组织的生命系统的相互作用以及它们潜在的作用场所仍不清楚。在这项工作中，我们证明了富勒烯衍生物可以穿过外部细胞膜，并且优先定位于线粒体。我们认为，我们的发现支持富勒烯作为药物递送剂的潜在用途，因为它们的结构模仿已知介导内吞作用的网格蛋白。 (C) 2002 年爱思唯尔科学（美国）。版权所有。
Fullerenes are a new class of compounds with potential uses in biology and medicine and many insights were made in the knowledge of their interaction with various biological systems. However, their interaction with organised living systems as well as the site of their potential action remains unclear. In this work, we have demonstrated that a fullerene derivative could cross the external cellular membrane and it localises preferentially to the mitochondria. We propose that our finding supports the potential use of fullerenes as drug delivery agents as their structure mimics that of clathrin known to mediate endocytosis. (C) 2002 Elsevier Science (USA). All rights reserved.