High-Resolution Computed Tomography Screening for Lung Cancer Unexpected Findings and New Controversies Regarding Adenocarcinogenesis
High-Resolution Computed Tomography Screening for Lung Cancer Unexpected Findings and New Controversies Regarding Adenocarcinogenesis
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DOI：
10.1043/1543-2165-134.1.41
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发表时间：
2010-01-01
影响因子：
4.6
通讯作者：
Flieder, Douglas B.
中科院分区：
文献类型：
--
作者：
Chirieac, Lucian R.;Flieder, Douglas B.
背景：人体成像技术的最新进展重新唤起了人们对肺癌筛查的兴趣。尽管历史和当前的初步和非对照研究并未显示筛查人群中肺癌死亡率的下降，但在肺癌界等待几项大型对照人群研究结果的同时，已经提出了许多解释。目的。-以肺癌筛查结果为背景，结合观察性病理学和放射学研究，批判性地回顾目前的腺癌发展模型。数据来源。-已发表的有关肺癌筛查、肺腺癌病理学和放射学的文章，可通过以下方式获取PubMed 构成了本次综述的基础。结论。-当前的腺癌发生模型可能对许多但不是所有肺腺癌有效。筛查数据与放射学和病理学研究相结合表明，并非所有肺腺癌都具有临床侵袭性，并且不确定是否所有侵袭性腺癌都源自已确定的癌前病变。 （Arch Pathol 实验室医学。2010 年；134：41-48）
Context.-Recent advances in human imaging technologies reawakened interest in lung cancer screening. Although historic and current preliminary and noncontrolled studies have not shown a decrease in lung cancer mortality in screened populations, many explanations have been proffered while the lung cancer community awaits the results of several large controlled population studies.Objective.-To critically review the current model of adenocarcinoma development against the background of lung cancer screening results combined with observational pathologic and radiographic studies.Data Sources.-Published articles pertaining to lung cancer screening, lung adenocarcinoma pathology, and radiology accessible through PubMed form the basis for this review.Conclusions.-The current adenocarcinogenesis model is probably valid for many but not all lung adenocarcinomas. Screening data combined with radiographic and pathologic studies suggest that not all lung adenocarcinomas are clinically aggressive, and it is uncertain whether all aggressive adenocarcinomas arise from identified precursors. (Arch Pathol Lab Med. 2010; 134: 41-48)