HOW TO MEASURE INDIRECT GENETIC EFFECTS: THE CONGRUENCE OF TRAIT-BASED AND VARIANCE-PARTITIONING APPROACHES
HOW TO MEASURE INDIRECT GENETIC EFFECTS: THE CONGRUENCE OF TRAIT-BASED AND VARIANCE-PARTITIONING APPROACHES
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DOI：
10.1111/j.1558-5646.2009.00676.x
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发表时间：
2009-07-01
期刊：
影响因子：
3.3
通讯作者：
Brodie, Edmund D., III
中科院分区：
文献类型：
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作者：
McGlothlin, Joel W.;Brodie, Edmund D., III
当一个个体的表型表达受到另一个同种个体的基因影响时，就会发生间接遗传效应（IGE），它可能会对选择的进化反应产生巨大影响。 IGE 的一般进化模型是使用源自母体效应理论的两个不同的理论框架开发的。第一个框架是基于特征的，重点关注社会伙伴的特定特征如何影响表型，以及矩阵 Psi 定义的交互强度。第二个框架将总遗传方差划分为代表直接影响、间接影响以及它们之间的协方差的组成部分，但没有识别导致 IGE 的特定社会特征。经验主义者更常采用后一种框架，因为估计方差分量的方法相对简单。在这里，我们展示了这两个理论框架如何相互关联，并推导出可用于在它们之间进行转换的方程。这种转化产生了一种通用方法，可用于通过标准定量遗传育种设计或自然种群的谱系来估计 Psi。该方法可用于非常一般的情况，并且广泛适用于所有 IGE，包括母体效应和亲属之间的其他相互作用。
Indirect genetic effects (IGEs), which occur when phenotypic expression in one individual is influenced by genes in another conspecific individual, may have a drastic effect on evolutionary response to selection. General evolutionary models of IGEs have been developed using two distinct theoretical frameworks derived from maternal effects theory. The first framework is trait-based and focuses on how phenotypes are influenced by specific traits in a social partner, with the strength of interactions defined by the matrix Psi. The second framework partitions total genetic variance into components representing direct effects, indirect effects, and the covariance between them, without identifying specific social traits responsible for IGEs. The latter framework has been employed more commonly by empiricists because the methods for estimating variance components are relatively straightforward. Here, we show how these two theoretical frameworks are related to each other and derive equations that can be used to translate between them. This translation leads to a generalized method that can be used to estimate Psi via standard quantitative genetic breeding designs or pedigrees from natural populations. This method can be used in a very general set of circumstances and is widely applicable to all IGEs, including maternal effects and other interactions among relatives.