Fluorinated Polymer Zwitterions: Choline Phosphates and Phosphorylcholines.
Fluorinated Polymer Zwitterions: Choline Phosphates and Phosphorylcholines.
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DOI：
10.1021/acsmacrolett.1c00451
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发表时间：
2021-09
影响因子：
5.8
通讯作者：
Le Zhou;Alexandria Triozzi;M. Figueiredo;T. Emrick
中科院分区：
文献类型：
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作者：
Le Zhou;Alexandria Triozzi;M. Figueiredo;T. Emrick
在两性离子结构中，磷酸胆碱（CP）基团因其获得将官能团直接嵌入两性离子部分中的新型化学组合物的能力而独特地具有吸引力。本文介绍了连接的氟化烷基基团的CP部分，产生两性离子单体1和2，证明经得起控制的自由基聚合和生产的一组新的含CP的氟化聚合物和共聚物与磷酰胆碱（PC）两性离子。氟化烃和两性离子的这种组合提供了新的，水溶性的聚合物两亲物，我们已经检查了在流体界面，涂层，在细胞培养，并在磁共振成像。
Among zwitterionic structures, the choline phosphate (CP) group is uniquely attractive for its ability to access novel chemical compositions that embed functional groups directly into the zwitterionic moiety. This paper describes the attachment of fluorinated alkyl groups to CP moieties, yielding zwitterionic monomers 1 and 2 that proved amenable to controlled free radical polymerization and the production of a new set of CP-containing fluorinated polymers and copolymers with phosphorylcholine (PC) zwitterions. This combination of fluorinated hydrocarbons and zwitterions affords novel, water-soluble polymeric amphiphiles that we have examined at fluid interfaces, as coatings, in cell culture, and in magnetic resonance imaging.