Inflammatory markers of lung disease in adult patients with cystic fibrosis
Inflammatory markers of lung disease in adult patients with cystic fibrosis
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DOI：
10.1002/ppul.20563
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发表时间：
2007-03-01
影响因子：
3.1
通讯作者：
Weiss, Scott T.
中科院分区：
文献类型：
--
作者：
Levy, Hara;Kalish, Leslie A.;Weiss, Scott T.
背景资料：与慢性细菌感染和炎症相关的进行性肺部疾病是囊性纤维化（CF）患者发病率和死亡率的主要原因。识别与肺损伤相关的炎症标志物可能有助于监测疾病进展和对治疗的反应。我们假设，血清生物标志物的水平将与CIF的临床过程中定义的肺功能测试（FEV1.Objective：为了确定是否与肺功能在成人CF的全身炎症生物标志物。方法：回顾性横断面分析63个人>= 30岁的儿童诊断CF，随后在儿童医院，波士顿。我们收集了人口统计学资料、CFTR基因型、1秒用力呼气量百分比（FEV 1）、C反应蛋白（CRP）、血清IgE和IgG、α（1）-抗胰蛋白酶、总白色血细胞和中性粒细胞计数以及中性粒细胞百分比。我们使用单变量分析和多元线性回归模型来检查全身炎症标志物是否随FEV 1（%预测值）而变化。结果如下：在包括CRP和另一种标志物的双协变量模型中，CRP（P < 0.001）和IgG（P = 0.02）与FEV 1（%预测值）显著相关。在CRP和IgG模型中，CRP每增加2倍，FEV 1预测值百分比降低4.91%（P < 0.0001），IgG每增加100 mg/dl，FEV 1预测值百分比降低1.56%（P = 0.02），校正DF 508 CFTR等位基因数量后，结果不变。在校正CRR后，任何其他标志物与FEV 1（%预测值）之间均无相关性。结论：在长期存活的成人CF患者中，肺部疾病的严重程度与CRP和IgG水平相关。我们的研究结果相关CRP和IgG水平和肺功能提供了一个基础，为后续的纵向研究和考虑新的疾病机制和结果测量。
Background: Progressive pulmonary disease associated with chronic bacterial infection and inflammation is the major cause of morbidity and mortality in cystic fibrosis (CF) patients. Identifying markers of inflammation that correlate with lung injury may be useful in monitoring disease progression and response to therapy. We hypothesized that levels of serum biomarkers would correlate with clinical course of CIF as defined by pulmonary function testing (FEV1).Objective: To determine whether biomarkers of systemic inflammation correlate with lung function in adults with CF.Methods: Retrospective cross-sectional analysis of 63 individuals >= 30 years of age diagnosed with CF in childhood and followed at Children's Hospital, Boston. We collected data on demographics, CFTR genotype, percent predicted forced expiratory volume in 1 sec (FEV1), C-reactive protein (CRP), serum IgE nd IgG, alpha(1)-antitrypsin, total white blood cell and neutrophil counts, and percent neutrophils. We used univariate analyses and multivariate linear regression modeling to examine whether markers of systemic inflammation varied with FEV1 (% predicted). Results: In two-covariate models including CRP and one other marker, CRP (P < 0.001) and IgG (P = 0.02) were significantly associated with FEV1 (% predicted). In the CRP and IgG model, percent predicted FEV1 decreased by 4.91% (P < 0.0001) for each twofold increase in CRP and by 1.56% (P = 0.02) for each 100 mg/dl increase in IgG.Results were unchanged by adjustment for number of DF 508 CFTR alleles. There was no association between any other marker and FEV1 (% predicted) after adjusting for CRRConclusion: Severity of lung disease in long surviving adult CF patients is correlated with CRP and IgG levels. Our findings relating CRP and IgG levels and lung function provide a foundation for subsequent longitudinal studies and consideration of novel disease mechanisms and outcome measurements.