Travelling gradients in interacting morphogen systems
Travelling gradients in interacting morphogen systems
复制标题
DOI：
10.1016/j.mbs.2007.01.006
复制
发表时间：
2007-09-01
影响因子：
4.3
通讯作者：
Maini, P. K.
中科院分区：
文献类型：
--
作者：
Baker, R. E.;Maini, P. K.
形态发生梯度在发育过程中扮演着重要的角色，但是这些梯度的形成和维持机制还不清楚。在这项工作中，我们调查是否存在的第二形态发生剂可以增加的鲁棒性的初级形态发生剂梯度扰动，从而提供了一个更稳定的发展机制。我们的模型基于成纤维细胞生长因子8和视黄酸的相互作用，它们已被证明在许多发育系统中起形态发生剂的作用。特别是，我们调查这些形态发生沿着脊椎动物胚胎的前后轴形成相反的梯度，从而控制轴分割和神经元分化的时间和空间方面。(C)2007爱思唯尔公司All rights reserved.
Morphogen gradients are well known to play several important roles in development; however the mechanisms underlying the formation and maintenance of these gradients are often not well understood. In this work, we investigate whether the presence of a secondary morphogen can increase the robustness of the primary morphogen gradient to perturbation, thereby providing a more stable mechanism for development. We base our model around the interactions of Fibroblast Growth Factor 8 and retinoic acid, which have been shown to act as morphogens in many developmental systems. In particular, we investigate the formation of opposing gradients of these morphogens along the antero-posterior axis of vertebrate embryos, thereby controlling temporal and spatial aspects of axis segmentation and neuronal differentiation. (C) 2007 Elsevier Inc. All rights reserved.