Basic study of less invasive high-intensity focused ultrasound (HIFU) in fetal therapy for twin reversed arterial perfusion (TRAP) sequence
Basic study of less invasive high-intensity focused ultrasound (HIFU) in fetal therapy for twin reversed arterial perfusion (TRAP) sequence
复制标题
微创高强度聚焦超声（HIFU）在双胞胎反向动脉灌注（TRAP）序列胎儿治疗中的基础研究
DOI：
10.1007/s10396-016-0725-x
复制
发表时间：
2016
影响因子：
1.8
通讯作者：
S. Umemura
中科院分区：
文献类型：
--
作者：
K. Ichizuka; R. Matsuoka;H. Aoki;J. Hasegawa;T. Okai;S. Umemura
本研究的目的是开发一种更适合临床应用于双胎反向动脉灌注（TRAP）序列治疗的高强度聚焦超声（HIFU）换能器。对3只家兔的肾分支血管进行HIFU治疗。顺序HIFU照射包含触发波、加热波和休息时间。HIFU治疗时间为10 s/疗程。结果在1.94 kW/cm 2的HIFU连续照射下，我们证实了在1.94 kW/cm 2的HIFU连续照射下，（空间平均时间平均强度）结论通过触发波和静息相证实了静脉和动脉同时闭塞使用为本研究创建的HIFU换能器治疗设备。临床应用似乎是可能的，并可能代表一个有前途的选择胎儿治疗涉及TRAP序列。
PurposeThe objective of the present study was to develop a high-intensity focused ultrasound (HIFU) transducer more suitable for clinical use in fetal therapy for twin reversed arterial perfusion (TRAP) sequence.Materials and methodsWe created a cooling and degassed water-circulating-type HIFU treatment device. HIFU was applied to renal branch vessels in three rabbits. Sequential HIFU irradiation contains a trigger wave, heating wave, and rest time. The duration of HIFU application was 10 s/course. Targeting could be achieved by setting the imaging probe in the center and placing the HIFU beam and imaging ultrasonic wave on the same axis.ResultWe confirmed under sequential HIFU irradiation with a total intensity of 1.94 kW/cm2(spatial average temporal average intensity) that the vein and artery were occluded in all three rabbits.ConclusionSimultaneous occluding of the veins and arteries was confirmed with trigger waves and a resting phase using the HIFU transducer treatment device created for this study. Clinical application appears possible and may represent a promising option for fetal therapy involving TRAP sequence.