End-tidal carbon dioxide concentration, carbon dioxide production, heart rate, and blood pressure as indicators of induced hyperthermia.
End-tidal carbon dioxide concentration, carbon dioxide production, heart rate, and blood pressure as indicators of induced hyperthermia.
复制标题
呼气末二氧化碳浓度、二氧化碳产生量、心率和血压作为诱导高热的指标。
DOI：
10.1007/bf02832141
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Schoenlein,WE
中科院分区：
文献类型：
--
作者：
delasAlas,V;Voorhees,WD;Geddes,LA;Bourland,JD;Schoenlein,WE
在4只自主呼吸的巴比妥酸麻醉犬中，用2,4-二硝基苯酚诱导热疗，同时连续测量直肠温度、心率、平均血压、潮末二氧化碳和二氧化碳产量（毫升/分钟）。后者是用一个气描仪（以获得呼吸量）和一个红外二氧化碳分析仪来测定吸入和过期的二氧化碳浓度。在五项生理测量中，二氧化碳产生的增加比直肠温度的升高早120多秒。在自发呼吸动物中，由于短暂性呼吸急促，潮末二氧化碳是一个不可靠的自发呼吸过程中接近高热的指标，潮末二氧化碳减少。二氧化碳产量（每分钟毫升数）立即增加，达到控制值的三到五倍。血压和心率是接近热疗的不敏感指标。
In 4 spontaneously breathing, barbiturate-anesthetized dogs, hyperthermia was induced with 2,4-dinitrophenol while rectal temperature, heart rate, mean blood pressure, end-tidal carbon dioxide, and carbon dioxide production (milliliters per minute) were measured continuously. The latter was determined with a pneumotachygraph (to obtain respired volume) and an infrared carbon dioxide analyzer that measured inspired and expired carbon dioxide concentration. Of the five physiologic measurements, the increase in carbon dioxide production preceded the increase in rectal temperature by more than 120 seconds. End-tidal carbon dioxide was an unreliable indicator in the spontaneously breathing animal of approaching hyperthermia during spontaneous breathing due to a transient tachypnea, which decreased end-tidal carbon dioxide. The carbon dioxide production (milliliters per minute) increased immediately and reached three to five times the control value. Blood pressure and heart rate were insensitive indicators of approaching hyperthermia.