Human papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: variation by geographical region, histological type and year of publication
Human papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: variation by geographical region, histological type and year of publication
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DOI：
10.1002/ijc.25396
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发表时间：
2011-02-15
影响因子：
6.4
通讯作者：
Clifford, Gary M.
中科院分区：
文献类型：
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作者：
Li, Ni;Franceschi, Silvia;Clifford, Gary M.
关于人乳头瘤病毒（HPV）在侵袭性宫颈癌（ICC）中的类型分布的汇总数据有助于预测HPV类型特异性疫苗和筛查试验的潜在影响，并了解HPV类型的致癌性。我们对1990年至2010年发表的HPV特定类型患病率数据进行了荟萃分析，其中包括243项研究和301348项ICC。在除亚洲以外的世界所有地区，与HPV16和/或18 （HPV16/18）相关的ICC比例在70%至76%之间。在西亚/中亚，82%的ICC与hpv16 /18相关，而在东亚只有68%。发现的12种最常见的HPV类型，按患病率递减顺序依次为HPV16（57%）、18（16%）、58、33、45、31、52、35、59、39、51和56。其他类型的流行，在系统发育上与上述相关，范围从
Pooled data on human papillomavirus (HPV) type distribution in invasive cervical cancer (ICC) can help to predict the potential impact of HPV type-specific vaccines and screening tests, and to understand the carcinogenicity of HPV types. We performed a meta-analysis of HPV type-specific prevalence data published from 1990 to 2010, including a total of 243 studies and 30,1348 ICC. The proportion of ICC associated with HPV16 and/or 18 (HPV16/18) was between 70 and 76% in all world regions except Asia. In Western/Central Asia, 82% of ICC was HPV16/18-associated compared to only 68% in Eastern Asia. The 12 most common HPV types identified, in order of decreasing prevalence, were HPV16 (57%), 18 (16%), 58, 33, 45, 31, 52, 35, 59, 39, 51 and 56. The prevalence of other types, phylogenetically related to those above, ranged from