Deciduomal responses in the uteri of ovariectomized golden hamsters, comparing progesterone and three closely related steroids applied in utero.
Deciduomal responses in the uteri of ovariectomized golden hamsters, comparing progesterone and three closely related steroids applied in utero.
复制标题
卵巢切除金仓鼠子宫内的蜕膜反应，比较孕酮和子宫内应用的三种密切相关的类固醇。
DOI：
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发表时间：
1978
影响因子：
3.6
通讯作者：
W. W. Leavitt
中科院分区：
文献类型：
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作者：
G. Blaha;W. W. Leavitt
四个密切相关的类固醇进行了测试，其蜕膜化作用在金黄地鼠子宫。这些化合物是孕酮、5 o-甾烷-3，20-二酮（DHP）、脱氧皮质酮（DOC）和A5-甾烯-3L3-醇-20-酮（甾烯醇酮）。通过将每种化合物溶解在半固体蜡-芝麻油混合物中并通过18号套管针将材料腔内注射来进行子宫内施用。除I组假孕对照外，所有仓鼠均切除卵巢。在卵巢切除术后第1天和第4天给药，并在第7天判断蜕膜发育。所有的治疗，包括孕激素产生最大的蜕膜，包括假孕组。DOC和DHP的蜕膜反应均较低，一些DHP子宫仅显示缺乏萎缩。孕烯醇酮和普通蜡没有反应，并允许子宫萎缩后，卵巢切除术。如先前的研究所示，几种类固醇在促进蜕膜形成中的相对有效性与它们对子宫孕酮受体蛋白的相对结合亲和力相关。
Four closely related steroids were tested for their decidualizing effect in uteri of golden hamsters. These compounds were progesterone, 5o-pregnane-3,20-dione (DHP), deoxycorticosterone (DOC) and A5�pregnen�3L3�ol�20.one (pregnenolone). Intrauterine application was done by dissolving each compound in a semisolid wax-sesame oil mixture and injecting the material intraluminally by means of an 18 gauge trocar. All hamsters were ovariectomized except for I group of pseudopregnant controls. Treatment was on Days 1 and 4 after ovariectomy and decidual development was judged on Day 7. All treatments which included progesterone gave the largest deciduomata, including the pseudopregnant group. Both DOC and DHP gave less decidual response, with some DHP uteri merely showing lack of atrophy. Pregnenolone and plain wax gave no responseand permitted uterineatrophyafterovariectomy. The relative effectiveness of the several steroids in promoting deciduomata was correlated with their relative binding affinities for uterine progesterone receptor proteins as indicated by previous studies.