Expansion of extracellular volume in early polycystic kidney disease.
Expansion of extracellular volume in early polycystic kidney disease.
复制标题
早期多囊肾病的细胞外容量扩张。
作者：
H. Danielsen;E. Pedersen;A. Nielsen;P. Herlevsen;H. Kornerup;V. Posborg
测定了 18 例成人多囊肾病患者的血容量 (BV)、细胞外容量 (ECV)、血压 (BP)、肌酐清除率 (CCr)、血浆血管紧张素 II (AII)、醛固酮 (Aldo) 和精氨酸加压素 (AVP) 水平以及血清渗透压 (Sosm)，其中 8 例血压正常（I 组），10 例高血压（II 组），10 例高血压（II 组）。 11 名对照受试者（第 III 组）。与第 III 组相比，第 I 组的 ECV 增加，但 BV 没有增加，而第 II 组和第 III 组之间的 BV 和 ECV 没有显着差异。 II组Aldo、AVP升高，AII有升高趋势，而I组激素水平与III组无显着差异。各组之间的 Sosm 没有显着差异。在合并患者组中，CCr 与 BV 和 ECV 呈正相关，与 BP 呈负相关。在患者中，AII 和 AVP 与血压呈正相关，但与 CCr 不呈正相关。结果表明，肾素-血管紧张素系统和AVP可能与血压升高有关，而ECV扩张可在血压不升高的情况下发现。
Blood volume (BV), extracellular volume (ECV), blood pressure (BP), creatinine clearance (CCr), plasma levels of angiotensin II (AII), aldosterone (Aldo) and arginine vasopressin (AVP), and serum osmolality (Sosm) were determined in 18 patients with adult polycystic kidney disease, 8 normotensive (group I), 10 hypertensive (group II), and in 11 control subjects (group III). ECV but not BV was increased in group I compared with group III, whereas BV and ECV did not differ significantly between groups II and III. In group II, Aldo and AVP were increased and AII tended to be increased, while in group I the hormone levels did not differ significantly from those in group III. Sosm did not differ significantly between the groups. In the combined patient group, CCr correlated positively with BV and ECV and negatively with BP. In the patients, AII and AVP were positively correlated with BP but not with CCr. The results suggest that both the renin-angiotensin system and AVP might be involved in the BP elevation, whereas expansion of ECV can be found without an increase in BP.