Tumour necrosis factor in the bronchoalveolar secretions of infants with the respiratory distress syndrome and the effect of dexamethasone treatment.
Tumour necrosis factor in the bronchoalveolar secretions of infants with the respiratory distress syndrome and the effect of dexamethasone treatment.
复制标题
呼吸窘迫综合征婴儿支气管肺泡分泌物中肿瘤坏死因子及地塞米松治疗的影响
作者：
S. Murch;T. T. MacDonald;C. Wood;K. Costeloe
BACKGROUND: Tumour necrosis factor alpha may contribute to the lung damage that occurs in the adult respiratory distress syndrome. Whether it occurs in the lungs of preterm infants with respiratory distress syndrome is unknown. METHODS: Tumour necrosis factor alpha concentrations in the bronchopulmonary secretions of 28 ventilated preterm infants were determined by the enzyme linked immunosorbent assay. RESULTS: Concentrations were low in the first three days of life, being undetectable in nine of the 20 infants whose bronchopulmonary secretions were sampled. From day 4 concentrations were increased and detectable in all but two of 14 infants. Similar concentrations were found in samples taken on days 8-20 and 21-40. Greater mean concentrations occurred in those infants requiring oxygen for a long time. In six infants who received dexamethasone treatment for prolonged ventilator dependency treatment was associated with a reduction in tumour necrosis factor alpha concentrations. CONCLUSIONS: Tumour necrosis factor may contribute to the neonatal respiratory distress syndrome, as suggested for the adult respiratory distress syndrome. The therapeutic effects of dexamethasone treatment in neonatal respiratory distress syndrome may be mediated, at least in part, by reduced production of pulmonary tumour necrosis factor.
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新生儿肺中性粒细胞和弹性蛋白酶/蛋白酶抑制剂失衡。
DOI：
10.1164/arrd.1984.130.5.817
发表时间：
1984
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Ogden,BE;Murphy,SA;Saunders,GC;Pathak,D;Johnson,JD
通讯作者：
Johnson,JD
肿瘤坏死因子诱导大鼠成年呼吸窘迫综合征。
DOI：
10.1001/archsurg.1989.01410120046010
发表时间：
1989
期刊：
Archives of surgery (Chicago, Ill. : 1960)
影响因子：
--
作者：
Ferrari-Baliviera,E;Mealy,K;Smith,RJ;Wilmore,DW
通讯作者：
Wilmore,DW
DOI：
10.1073/pnas.82.24.8667
发表时间：
1985-12-01
影响因子：
11.1
作者：
GAMBLE, JR;HARLAN, JM;VADAS, MA
通讯作者：
VADAS, MA
影响因子：
15.9
作者：
ANTONIADES, HN;BRAVO, MA;SELMAN, M
通讯作者：
SELMAN, M
肿瘤坏死因子-α 抑制肺表面活性蛋白的表达。
DOI：
10.1172/jci114929
发表时间：
1990
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Wispe,JR;Clark,JC;Warner,BB;Fajardo,D;Hull,WE;Holtzman,RB;Whitsett,JA
通讯作者：
Whitsett,JA