Mice alternate between discrete strategies during perceptual decision-making.
Mice alternate between discrete strategies during perceptual decision-making.
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DOI：
10.1038/s41593-021-01007-z
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发表时间：
2022-03
影响因子：
25
通讯作者：
Pillow JW
中科院分区：
文献类型：
--
作者：
Ashwood ZC;Roy NA;Stone IR;International Brain Laboratory;Urai AE;Churchland AK;Pouget A;Pillow JW
知觉决策的经典模型假设受试者使用单一的、一致的策略来形成决策，或者策略随着时间的推移缓慢演变。在这里，我们提出了新的分析，表明这种普遍的观点是不正确的。我们分析了老鼠和人类决策实验的数据，发现选择行为依赖于多个交错策略之间的相互作用。这些策略以隐马尔可夫模型中的状态为特征，在切换之前持续数十到数百次试验，并且可能在一个会话中交替多次。确定的老鼠决策策略在不同的个体中高度一致，并包括单一的“参与”状态，其中的决策严重依赖于感官刺激，以及几个经常发生错误的有偏见的状态。这些结果为在啮齿动物心理物理实验中经常观察到的“失误”提供了一个强有力的替代解释，并表明标准的表现衡量标准掩盖了试验中策略发生戏剧性变化的存在。
Classical models of perceptual decision-making assume that subjects use a single, consistent strategy to form decisions, or that strategies evolve slowly over time. Here we present new analyses suggesting that this common view is incorrect. We analyzed data from mouse and human decision-making experiments and found that choice behavior relies on an interplay between multiple interleaved strategies. These strategies, characterized by states in a hidden Markov model, persist for tens to hundreds of trials before switching, and may alternate multiple times within a session. The identified mouse decision-making strategies were highly consistent across individuals and comprised a single “engaged” state, in which decisions relied heavily on the sensory stimulus, and several biased states in which errors frequently occurred. These results provide a powerful alternate explanation for “lapses” often observed in rodent psychophysical experiments, and suggest that standard measures of performance mask the presence of dramatic changes in strategy across trials.
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影响因子：
8.8
作者：
Burgess CP;Lak A;Steinmetz NA;Zatka-Haas P;Bai Reddy C;Jacobs EAK;Linden JF;Paton JJ;Ranson A;Schröder S;Soares S;Wells MJ;Wool LE;Harris KD;Carandini M
通讯作者：
Carandini M
影响因子：
16.2
作者：
Ding L;Gold JI
通讯作者：
Gold JI
影响因子：
19.9
作者：
Fiser, Jozsef;Berkes, Pietro;Orban, Gergo;Lengyel, Mate
通讯作者：
Lengyel, Mate
影响因子：
64.8
作者：
Daw, Nathaniel D.;O'Doherty, John P.;Dayan, Peter;Seymour, Ben;Dolan, Raymond J.
通讯作者：
Dolan, Raymond J.
影响因子：
2
作者：
GOLDFARB, D
通讯作者：
GOLDFARB, D