Gene therapy takes a cue from HAART: combinatorial antiviral therapeutics reach the clinic.
Gene therapy takes a cue from HAART: combinatorial antiviral therapeutics reach the clinic.
复制标题
基因治疗借鉴了HAART：组合抗病毒疗法进入临床。
DOI：
10.1126/scitranslmed.3001298
复制
发表时间：
2010
影响因子：
17.1
通讯作者：
Schaffer,DavidV
中科院分区：
文献类型：
--
作者：
Shah,PriyaS;Schaffer,DavidV
科学家们首次测试了三种基于 RNA 的基因疗法的组合，通过慢病毒载体传递，以针对患者的艾滋病毒。这项研究不仅证明了这种方法的安全性和长期可行性，而且还强调了基因治疗策略的重点改进可能对将实验室的承诺转化为临床疗效产生最大影响的领域。
For the first time, scientists have tested a combination of three RNA-based gene therapies, delivered via a lentiviral vector, to target HIV in patients. This study not only demonstrates the safety and long-term viability of this approach, but also highlights areas in which focused improvements in gene therapy strategies may provide the most impact in increasingly translating promise in the laboratory to efficacy in the clinic.