The Burden of Cancer and Pre-cancerous Conditions Among Transgender Individuals in a Large Healthcare Network.
The Burden of Cancer and Pre-cancerous Conditions Among Transgender Individuals in a Large Healthcare Network.
复制标题
大型医疗网络中跨性别者的癌症和癌前病变负担。
DOI：
10.1101/2024.03.24.24304777
复制
发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Guo,Yi
中科院分区：
文献类型：
--
作者：
Yang,Shuang;Li,Yongqiu;Wheldon,ChristopherW;Prosperi,Mattia;George,ThomasJ;Shenkman,ElizabethA;Wang,Fei;Bian,Jiang;Guo,Yi
目前的研究旨在检查癌症和癌前疾病的患病率和风险因素，比较跨性别和顺性别个体，使用来自大型医疗保健系统的2012-2023年电子健康记录数据。我们使用先前验证的可计算表型确定了2，745名变性人和54，900名匹配的顺性别个体。我们计算了与人乳头瘤病毒（HPV），人类免疫缺陷病毒（HIV），烟草，酒精，肺，乳腺，结肠直肠相关的癌症和癌前病变的患病率，并建立了多变量logistic模型来检查性别认同与癌症或癌前病变之间的关联。结果表明，不同性别身份的人患癌症的几率相似，但跨性别者患癌前病变的风险显著较高，包括与顺性别女性相比的酒精相关、乳腺癌和结直肠癌前病变，以及与顺性别男性相比的HPV相关、烟草相关、酒精相关和结直肠癌前病变。这些研究结果强调，有必要采取针对性的干预措施和政策，解决影响跨性别人群的癌症健康差异。
The current study aimed to examine the prevalence of and risk factors for cancer and pre-cancerous conditions, comparing transgender and cisgender individuals, using 2012-2023 electronic health record data from a large healthcare system. We identified 2,745 transgender individuals using a previously validated computable phenotype and 54,900 matched cisgender individuals. We calculated the prevalence of cancer and pre-cancer related to human papillomavirus (HPV), human immunodeficiency virus (HIV), tobacco, alcohol, lung, breast, colorectum, and built multivariable logistic models to examine the association between gender identity and the presence of cancer or pre-cancer. Results indicated similar odds of developing cancer across gender identities, but transgender individuals exhibited significantly higher risks for pre-cancerous conditions, including alcohol-related, breast, and colorectal pre-cancers compared to cisgender women, and HPV-related, tobacco-related, alcohol-related, and colorectal pre-cancers compared to cisgender men. These findings underscore the need for tailored interventions and policies addressing cancer health disparities affecting the transgender population.