Hepatocellular cancer: The impact of obesity, type 2 diabetes and a multidisciplinary team
Hepatocellular cancer: The impact of obesity, type 2 diabetes and a multidisciplinary team
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DOI：
10.1016/j.jhep.2013.08.011
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发表时间：
2014-01-01
影响因子：
25.7
通讯作者：
Reeves, Helen L.
中科院分区：
文献类型：
--
作者：
Dyson, Jessica;Jaques, Bryan;Reeves, Helen L.
背景和目标：肝细胞癌（HCC）通常并发慢性肝病和发病率的增加，尽管已报告的病毒性hepatitis.Methods的患病率下降：以下介绍了集中的专家团队管理癌症患者在英格兰，我们的特点是肝癌患者的人口统计资料提到的纽卡斯尔upon泰恩医院NHS基金会2000年至2010年之间的信任。区域HCC死亡率数据来自Public Health England.Results：该地区HCC相关死亡率在10年内上升了1.8倍，从每10万人中2.0人上升到3.7人。集中审查了632例病例，与丙型肝炎、酒精性肝病或无慢性肝病相关的患者转诊增加2-3倍，与非酒精性脂肪性肝病（NAFLD）相关的HCC增加>10倍。到2010年，NAFLD占41/118例（34.8%）。不考虑相关病因，2010年78/118例（66.1%）病例中存在代谢风险因素，与肥胖和糖尿病的区域性增加相关。中位总生存期仅为10.7个月。尽管NAFLD相关HCC患者年龄较大（71.3岁vs 67.1岁; p
Background & Aims: Hepatocellular cancer (HCC) commonly complicates chronic liver disease and increases in incidence have been reported despite falling prevalences of viral hepatitis.Methods: Following the introduction of centralised specialist teams to manage patients with cancer in England, we characterised the demographics of patients with HCC referred to the Newcastle- upon-Tyne Hospitals NHS Foundation Trust between 2000 and 2010. Regional HCC mortality data was from Public Health England.Results: HCC related mortality in the region rose 1.8 fold in 10 years, from 2.0 to 3.7 per 100,000. 632 cases were reviewed centrally, with 2-3 fold increases in referrals of patients with associated hepatitis C, alcoholic liver disease or no chronic liver disease and a >10 fold increase in HCC associated with non-alcoholic fatty liver disease (NAFLD). By 2010 NAFLD accounted for 41/118 (34.8%) cases. Irrespective of associated etiologies, metabolic risk factors were present in 78/118 (66.1%) cases in 2010, associated with regional increases in obesity and diabetes. Median overall survival was just 10.7 months. Although patients with NAFLD associated HCC were older (71.3 yr vs. 67.1 yr; p