Helicobacter pylori infection is correlated with the incidence of erosive oral lichen planus and the alteration of the oral microbiome composition.
Helicobacter pylori infection is correlated with the incidence of erosive oral lichen planus and the alteration of the oral microbiome composition.
复制标题
幽门螺杆菌感染与糜烂性口腔扁平苔藓的发生率和口腔微生物组成的改变相关
DOI：
10.1186/s12866-021-02188-0
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发表时间：
2021-04-20
期刊：
影响因子：
4.2
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Li S;Zhang Y;Yang Z;Li J;Li Y;Li H;Li W;Jia J;Ge S;Sun Y
口腔扁平苔藓（oral lichen planus，OLP）是一种常见的口腔疾病，与恶变的危险性增加有关。OLP的发病机制尚不清楚。口腔菌群失调是OLP的病因之一。虽然幽门螺杆菌感染与多种口腔疾病有关，但H.幽门螺杆菌感染和OLP尚不清楚。本研究旨在探讨H.幽门螺杆菌感染对OLP发病机制和口腔微生物组成的影响。结果收集30例OLP患者（OLP组）和21例阴性对照者（NC组）的唾液标本。采用碳13标记的尿素呼气试验（UBT）检测幽门螺杆菌感染。根据H.幽门螺杆菌H. pylori阳性OLP（OLP+）、H. pylori阳性NC（NC+）、H. pylori阴性OLP（OLP-）和H.幽门阴性NC（NC-）。口腔微生物组组成在OLP和NC组之间以及OLP −和OLP+组之间存在显著差异。与OLP −组相比，OLP+组的糜烂性OLP发生率更高，唾液细胞因子水平更高。相比之下，口腔微生物组成和细胞因子水平之间没有显着差异NC −和NC + groups.Conclusions这是第一份报告，证明H。幽门螺杆菌感染与糜烂型OLP的发病密切相关。
BackgroundOral lichen planus (OLP), a common clinical oral disease, is associated with an increased risk of malignant transformation. The mechanism underlying the pathogenesis of OLP is unknown. Oral dysbacteriosis is reported to be one of the aetiological factors of OLP. AlthoughHelicobacter pyloriinfection is associated with various oral diseases, the correlation betweenH. pyloriinfection and OLP is unclear. This study aimed to investigate the effect ofH. pyloriinfection on OLP pathogenesis and oral microbiome composition in the Chinese population, which has a high incidence ofH. pyloriinfection.ResultIn this study, saliva samples of 30 patients with OLP (OLP group) and 21 negative controls (NC group) were collected.H. pyloriinfection was detected using the carbon-13-labeled urea breath test (UBT). The saliva samples were divided into the following four groups based on theH. pyloristatus:H. pylori-positive OLP (OLP+),H. pylori-positive NC (NC+),H. pylori-negative OLP (OLP−), andH. pylori-negative NC (NC−). Oral microbiome compositions were significantly different between the OLP and NC groups and between the OLP− and OLP+ groups. Compared with those in the OLP− group, those in the OLP+ group had a higher incidence of erosive OLP and higher levels of salivary cytokines. In contrast, the oral microbiome composition and cytokine levels were not significantly different between the NC− and NC+ groups.ConclusionsThis is the first report to demonstrate thatH. pyloriinfection is significantly correlated with the pathogenesis of erosive OLP.