CELLULAR TRANSPORT OF LONG CHAIN FATTY ACIDS.
CELLULAR TRANSPORT OF LONG CHAIN FATTY ACIDS.
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长链脂肪酸的细胞运输。
DOI：
10.1139/o64-107
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发表时间：
1964
期刊：
影响因子：
--
通讯作者：
J. Evans
中科院分区：
文献类型：
--
作者：
J. Evans
长链非酯化脂肪酸的细胞转运涉及脂肪酸在白蛋白上的细胞外结合位点与细胞膜和细胞器上的组织结合位点之间的转移。组织磷脂和低级甘油酯不作为脂肪酸进入细胞的主要受体。缺乏能源依赖运输过程的证据；然而，影响脂肪酸利用的活跃细胞代谢的改变可能通过改变脂肪酸从组织结合位点的清除率来间接影响转运。非酯化脂肪酸从脂肪组织的释放以及心肌和其他组织的摄取受到脂肪酸浓度和细胞外液中脂肪酸与白蛋白的摩尔比的影响，并且可能还受到细胞内脂肪酸结合位点的容量和周转率的影响。脂肪酸的运输和分子结构之间的关系可能归因于溶解度、蛋白质...
Cellular transport of long chain nonesterified fatty acids involves transfer of fatty acids between extracellular binding sites on albumin and tissue binding sites on cell membranes and organelles. Tissue phospholipids and lower glycerides do not serve as primary acceptors for fatty acid entering the cell. Evidence for an energy-dependent transport process is lacking; however, alterations in active cellular metabolism which influence utilization of fatty acids may indirectly affect transport by changing the rate of clearance of fatty acids from tissue binding sites. Release of nonesterified fatty acids from adipose tissue, and uptake by heart muscle and other tissues are influenced by fatty acid concentration and the molar ratio of fatty acid to albumin in extracellular fluid, and probably as well by the capacity and turnover rate of binding sites for fatty acid within the cells. The relationship between transport and molecular structure of fatty acids may be attributed to differences in solubility, prote...