Minimum incidence of primary cervical dystonia in a multiethnic health care population
Minimum incidence of primary cervical dystonia in a multiethnic health care population
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DOI：
10.1212/01.wnl.0000267425.51598.c9
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发表时间：
2007-08-14
期刊：
影响因子：
9.9
通讯作者：
Tanner, C. M.
中科院分区：
文献类型：
--
作者：
Marras, C.;Van den Eeden, S. K.;Tanner, C. M.
背景资料：现有的两种原发性宫颈肌张力障碍发病率的估计是基于对欧洲血统的相对种族同质人群的观察结果。目的：估计北方加州健康维护组织的多种族成员中原发性宫颈肌张力障碍的最低发病率。使用电子医疗记录和医疗图表审查的组合，结果：从820万人年的观察中，我们确定了66例颈肌张力障碍的发病病例。该人群中颈部肌张力障碍发病率的最低估计值为0.80/100，000人年。计算了30岁以上个体的种族特异性发病率。白色个体的发病率（1.23/100，000人-年）高于其他种族的人（0.15/100，000人-年，p < 0.0001）。女性的最低估计发病率是男性的2.5倍（1.14 vs 0.45/100，000人-年，p = 0.0005）。女性的平均诊断年龄（56岁）高于男性（45岁，p = 0.0004）。有没有显着差异，在报告的症状持续时间之前，女性和男性之间的诊断（3.9与5.3年）。结论：估计发病率之间的诊断颈部肌张力障碍的白色个人在这北方加利福尼亚州的人口是类似于以前的估计，在更种族同质的人口，主要是欧洲血统。其他种族，包括西班牙裔、亚裔和黑人的发病率似乎明显较低。女性的发病率也高于男性。
Background: The two existing estimates of the incidence of primary cervical dystonia were based on observations in relatively ethnically homogeneous populations of European descent.Objective: To estimate the minimum incidence of primary cervical dystonia in the multiethnic membership of a health maintenance organization in Northern California.Methods: Using a combination of electronic medical records followed by medical chart reviews, we identified incident cases of cervical dystonia first diagnosed between 1997 and 1999.Results: We identified 66 incident cases of cervical dystonia from 8.2 million person-years of observation. The minimum estimate of the incidence of cervical dystonia in this population is 0.80 per 100,000 person-years. Ethnicity-specific incidence rates were calculated for individuals over age 30. Incidence was higher in white individuals (1.23 per 100,000 person-years) than in persons of other races ( 0.15 per 100,000 person-years, p < 0.0001). The minimum estimated incidence was 2.5 times higher in women than in men (1.14 vs 0.45 per 100,000 person-years, p = 0.0005). The average age at diagnosis was higher in women ( 56 years) than in men ( 45 years, p = 0.0004). There was no significant difference in reported symptom duration prior to diagnosis between women and men (3.9 vs 5.3 years).Conclusion: The estimated incidence of diagnosed cervical dystonia among white individuals in this Northern Californian population is similar to previous estimates in more ethnically homogeneous populations of largely European descent. The incidence in other races, including Hispanic, Asian, and black appears to be significantly lower. The incidence is also higher in women than in men.