Flickering Red-Light Stimulus for Promoting Coherent 40 Hz Neural Oscillation: A Feasibility Study.
Flickering Red-Light Stimulus for Promoting Coherent 40 Hz Neural Oscillation: A Feasibility Study.
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DOI：
10.3233/jad-200179
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Figueiro MG
中科院分区：
文献类型：
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作者：
Sahin L;Figueiro MG
相干40 Hz（伽马）神经振荡表明健康的大脑活动，并且已知在阿尔茨海默病（AD）患者中被破坏。已知通过闪烁光的40 Hz夹带显著减弱小鼠中的AD病理。证明使用照明干预促进连贯的40 Hz神经振荡，改善工作记忆表现，并减少健康年轻人群体中的主观嗜睡的可行性。如果成功，干预措施可以扩展到解决与轻度认知障碍和AD相关的认知障碍。9名健康参与者（中位年龄22岁，5名女性）以受试者内平衡的方式暴露于每次会议的两种照明条件之一。研究的两个阶段间隔1周。定制的光掩模提供40 Hz闪烁红光（FRL）干预或黑暗控制条件（即，完全黑暗，光罩未通电）。每个阶段收集四次数据：暴露前、暴露25分钟后、暴露50分钟后和暴露后。每个数据收集期包括Karolinska嗜睡量表报告、脑电图和工作记忆（n-back）听觉性能测试。FRL干预导致40 Hz功率显著增加，低伽马功率适度增加。与对照组相比，干预对工作记忆表现和主观嗜睡没有显着影响。然而，40 Hz功率的增加与主观嗜睡的减少显著相关。结果清楚地证明了使用闪烁光来增加40 Hz功率的可行性。
Coherent 40 Hz (gamma) neural oscillation indicates healthy brain activity and is known to be disrupted in Alzheimer’s disease (AD) patients. 40 Hz entrainment by flickering light is known to significantly attenuate AD pathology in mice. To demonstrate the feasibility of using a lighting intervention to promote coherent 40 Hz neural oscillation, improved working memory performance, and reduced subjective sleepiness among a population of healthy young adults. If successful, the intervention could be extended to address cognitive impairment associated with mild cognitive impairment and AD. Nine healthy participants (median age 22 years, five females) were exposed to one of two lighting conditions per session in a within-subjects counterbalanced manner. The study’s two sessions were separated by 1 week. Custom-built light masks provided either a 40Hz flickering red light (FRL) intervention or a dark control condition (i.e., total darkness, light mask not energized) at participants’ eyes. Data were collected four times per session: pre-exposure, after 25-min exposure, after 50-min exposure, and post-exposure. Each data collection period included a Karolinska Sleepiness Scale report, an electroencephalogram, and working memory (n-back) auditory performance testing. The FRL intervention induced a significant increase in 40 Hz power and a modest increase in low gamma power. The intervention had no significant impact on working memory performance and subjective sleepiness compared to the control. However, increases in 40 Hz power were significantly correlated with reduced subjective sleepiness. The results clearly demonstrate the feasibility of using a flickering light to increase 40 Hz power.