Controlled release of chlorhexidine diacetate from a porous methacrylate system: Supercritical fluid assisted foaming and impregnation
Controlled release of chlorhexidine diacetate from a porous methacrylate system: Supercritical fluid assisted foaming and impregnation
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DOI：
10.1002/jps.20850
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发表时间：
2007-08-01
影响因子：
3.8
通讯作者：
Darr, J. A.
中科院分区：
文献类型：
--
作者：
Gong, K.;Braden, M.;Darr, J. A.
研究了二醋酸氯己定（CX）从基于聚甲基丙烯酸乙酯和甲基丙烯酸四氢糠酯（PEM/THFM）的自固化聚合物体系中的释放。采用超临界流体辅助浸渍发泡法制备了CX-PEM/THFM多孔释药体系。X射线衍射（XRD）和差示扫描量热法（DSC）表明，超临界处理后CX的结晶度明显降低，而拉曼光谱表明产物中CX与PEM之间存在氢键作用。紫外-可见光溶解研究表明，药物释放速率在SCF处理的药物递送系统中几乎是常规固化样品的七倍。(c)2007 Wiley-Liss，Inc.
The release of chlorhexidine diacetate (CX) from a self-curing polymeric system based on poly(ethylmethacrylate) and tetrahydrofurfurylmethacrylate (PEM/THFM) was developed in this study. Supercritical fluid assisted impregnation and foaming was employed for preparing porous CX-PEM/THFM drug release system. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) show that the crystallinity of CX significantly decreased after supercritical processing, whilst Raman spectroscopy suggested a hydrogen bonding interaction between the CX and PEM in the product. A UV-Vis dissolution study revealed that the drug release rate is almost as seven times faster in the SCF processed drug delivery system than conventional cured samples. (c) 2007 Wiley-Liss, Inc.