Localization and possible function of peptidergic neurons and their interactions with central catecholamine neurons, and the central actions of gut hormones.
Localization and possible function of peptidergic neurons and their interactions with central catecholamine neurons, and the central actions of gut hormones.
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肽能神经元的定位和可能的功能及其与中枢儿茶酚胺神经元的相互作用，以及肠道激素的中枢作用。
DOI：
10.1210/jcem-50-6-994
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
J. Gustafsson
中科院分区：
文献类型：
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作者：
K. Fuxe;K. Andersson;T. Hökfelt;V. Mutt;L. Ferland;L. Agnati;D. Ganten;S. Said;P. Eneroth;J. Gustafsson
在大鼠的肠道和下丘脑中描述了各种神经肽的定位。证据是存在的材料类似促肾上腺皮质激素样中间肽在弓状和弓状周围神经元，投射到各种下丘脑核，边缘区和丘脑。β-内啡肽和胰高血糖素减少正中隆起的多巴胺周转，而促胰液素增加多巴胺周转，血管活性肠多肽（VIP）没有影响。β-内啡肽、VIP、胰泌素和胰高血糖素都在各种下丘脑核团中产生去甲肾上腺素周转的离散变化。主要观察到去甲肾上腺素周转增加。这些儿茶酚胺周转变化似乎引起催乳素和生长激素分泌的变化。因此，结果表明，肠道激素和阿片肽可能直接作用于下丘脑的特定类型受体，参与控制下丘脑功能，例如控制垂体前叶的激素分泌和食物摄入。在某些情况下，从胃肠道释放到循环中的胃肠道肽似乎可以到达下丘脑并通过上述机制调节其活性。因此，可以推测，胃肠功能紊乱可能通过调节下丘脑活动导致摄食的病理变化。
The localization of various neuropeptides is described in the gut and in the hypothalamus in the rat. Evidence is given for the presence of material resembling corticotropin-like intermediate peptide in arcuate and periarcuate neurons, projecting to various hypothalamic nuclei, limbic areas and the thalamus. beta-Endorphin and glucagon decrease dopamine turnover in the median eminence, while secretin increases dopamine turnover and vasoactive intestinal polypeptide (VIP) has no effect. beta-Endorphin, VIP, secretin, and glucagon all produce discrete changes in norepinephrine turnover in various hypothalamic nuclei. Mainly increases of norepinephrine turnover were observed. These catecholamine turnover changes appear to cause changes in the secretion of prolactin and growth hormone. The results therefore indicate that gut hormones and opioid peptides may act directly on the hypothalamus on specific types of receptors to participate in the control of hypothalamic functions such as control of hormone secretion from the anterior pituitary and of food intake. It seems possible that gastrointestinal peptides released from the gastrointestinal tract into the circulation under certain circumstances could reach the hypothalamus and modulate its activity via the above-mentioned mechanisms. It may therefore be speculated that disturbances in gastrointestinal functions could lead to pathological changes in food intake via modulation of hypothalamic activity.