Management of Malignant Melanoma [Abridged]
Management of Malignant Melanoma [Abridged]
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恶性黑色素瘤的治疗[删节]
DOI：
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发表时间：
1969
期刊：
影响因子：
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通讯作者：
Oliver C. Lloyd
中科院分区：
文献类型：
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作者：
Oliver C. Lloyd
恶性黑色素瘤合并多发性皮肤转移的病例并不总是均匀进展的。在某些情况下，这种情况似乎会持续多年；旧的皮损消失，新的皮损出现。当像这样的病变变得复杂时，它就会干涸，结壳脱落，留下粉红色的痕迹。显微镜下可见真皮内残留少量恶性黑素细胞，血管增多，圆形细胞浸润明显，有许多噬黑素细胞，这是先前活动的结果。消退更常见于部分恶性黑色素瘤，例如当部分色素斑块变白时。这类肿瘤的预后好于平均水平。恶性黑色素瘤的消退或消退可以用细胞免疫来解释。恶性黑色素瘤的发展经历了三个阶段(Lloyd 1954,1964，Petersen等人)。1962年)。这些分期是基于侵袭的程度，但它们也代表了恶性程度。
Cases of malignant melanoma with multiple skin metastasis are not always uniformly progressive. In some cases the condition appears to remain stationary for years; old lesions die off and new ones appear. When a lesion like this involutes, it dries up and a crust falls off, leaving a pink mark. Microscopical section may show a few residual malignant melanocytes in the dermis, together with increased vascularity, well-marked round cell infiltration and many melanophages, the result of previous activity. Regression is more commonly seen in part of a malignant melanoma, as for instance when part of the pigmented patch blanches. Such tumours have a better than average prognosis. Regression or involution of a malignant melanoma can be explained in terms of cellular immunity. Three stages in the development of malignant melanoma have been described (Lloyd 1954, 1964, Petersen et al. 1962). These stages are based on the degree of invasion, but they also represent degrees of malignancy.