Spontaneous curvature and thermodynamic stability of mixed amphiphilic layers
Spontaneous curvature and thermodynamic stability of mixed amphiphilic layers
复制标题
混合两亲层的自发曲率和热力学稳定性
DOI：
--
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
A. Ben
中科院分区：
文献类型：
--
作者：
S. May;A. Ben
用两种分子水平模型研究了由两种不同链长的两亲性组分组成的混合双层膜的弹性行为。在这两种情况下，双层自由能表示为链，头基和界面的贡献以及混合熵项的总和。头群和界面项建模使用简单的现象，但一般的表达式。不同的模型在他们的治疗链构象自由能。在一种情况下，它是使用详细的平均场分子理论计算的。另一种是基于简单的“压缩"模型。这两种模型得出了相似的结论。表达的双层自由能作为其两个单层贡献的总和，进行热力学稳定性分析，以检查自发囊泡形成的可能性。为此，我们展开的双层自由能作为一个幂级数（高达二阶）的单层曲率，其两亲性组合物和平均分子量。
The elastic behavior of mixed bilayers composed of two amphiphilic components with different chain length (and identical head groups) is studied using two molecular level models. In both, the bilayer free energy is expressed as a sum of chain, head group and interfacial contributions as well as a mixing entropy term. The head group and interfacial terms are modeled using simple phenomenological but general expressions. The models differ in their treatment of the chain conformational free energy. In one it is calculated using a detailed mean‐field molecular theory. The other is based on a simple ‘‘compression’’ model. Both models lead to similar conclusions. Expressing the bilayer free energy as a sum of its two monolayer contributions, a thermodynamic stability analysis is performed to examine the possibility of spontaneous vesicle formation. To this end, we expand the bilayer free energy as a power series (up to second order) in terms of the monolayer curvatures, their amphiphilic compositions and the av...
影响因子：
2.9
作者：
ALMOG, S;LITMAN, BJ;LICHTENBERG, D
通讯作者：
LICHTENBERG, D