Fibronectin: An interesting vocal fold protein
Fibronectin: An interesting vocal fold protein
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DOI：
10.1016/s0892-1997(02)00102-9
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发表时间：
2002-09-01
期刊：
影响因子：
2.2
通讯作者：
Thibeault, SL
中科院分区：
文献类型：
--
作者：
Hirschi, SD;Gray, SD;Thibeault, SL
关于细胞外基质的功能有大量的信息。曾经被认为只是一个围绕细胞的结构实体，现在知道它做得更多。纤连蛋白尤其受到特别关注。纤连蛋白是一种普遍存在的糖蛋白，在再生、愈合和胚胎组织的细胞外基质中最丰富。大量的证据支持这样一个事实，即纤维连接蛋白参与了整个身体中与声带生物学相关的许多不同功能。本文介绍了纤维连接蛋白及其亚型的结构，并介绍了它所发挥的许多功能。并对纤维连接蛋白在声带及声带病理中的作用进行了综述。讨论了纤维连接蛋白在声带小结、声带息肉、声带瘢痕和Reinke水肿中的存在，并回顾了其在粘膜波损伤中的作用。最后，它讨论了初步的微阵列数据显示，纤维连接蛋白的基因表达上调，在真正的声带相比，假声带。
A great deal of information is accruing regarding the function of the extracellular matrix. Once thought to be simply a structural entity to surround cells, it is now known to do much more. Fibronectin in particular has received specific attention. Fibronectin is a ubiquitous glycoprotein found most abundantly in the extracellular matrix of regenerating, healing, and embryonic tissue. Vast evidence supports the fact that fibronectin participates in many diverse functions throughout the body that are relevant to vocal fold biology. This article introduces the structure of fibronectin and its isoforms and provides an introduction to some of the many functions it plays. It also reviews the evidence about fibronectin's place in vocal folds and vocal fold pathology. It discusses fibronectin's presence in vocal nodules, vocal polyps, vocal scarring, and Reinke's edema, and reviews the data on its role in mucosal wave impairment. Lastly, it discusses preliminary microarray data that show gene expression for fibronectin to be upregulated in true vocal folds when compared to false vocal folds.