Transient inhibition of DNA synthesis by 5-fluorodeoxyuridine leads to overexpression of dihydrofolate reductase with increased frequency of methotrexate resistance.

Transient inhibition of DNA synthesis by 5-fluorodeoxyuridine leads to overexpression of dihydrofolate reductase with increased frequency of methotrexate resistance.
复制标题

5-氟脱氧尿苷短暂抑制 DNA 合成会导致二氢叶酸还原酶过度表达,从而增加甲氨蝶呤耐药频率。

DOI:
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发表时间:
1988
期刊:
The Journal of biological chemistry
影响因子:
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通讯作者:
Westin,EH
Westin,EH
中科院分区:
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文献类型:
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作者:
Schuetz,JD;Gorse,KM;Goldman,ID;Westin,EH

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